Sex-Specific Differences in Kidney Function and Blood Pressure Regulation

IF 4.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Molecular Sciences Pub Date : 2024-08-08 DOI:10.3390/ijms25168637

Eleni Stamellou, Viktor Sterzer, Jessica Alam, Stefanos Roumeliotis, Vasillios Liakopoulos, E. Dounousi

引用次数: 0

Abstract

Premenopausal women generally exhibit lower blood pressure and a lower prevalence of hypertension than men of the same age, but these differences reverse postmenopause due to estrogen withdrawal. Sexual dimorphism has been described in different components of kidney physiology and pathophysiology, including the renin–angiotensin–aldosterone system, endothelin system, and tubular transporters. This review explores the sex-specific differences in kidney function and blood pressure regulation. Understanding these differences provides insights into potential therapeutic targets for managing hypertension and kidney diseases, considering the patient’s sex and hormonal status.

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肾功能和血压调节的性别差异

与同龄男性相比，绝经前女性的血压通常较低，高血压发病率也较低，但绝经后由于雌激素的减少，这些差异会逆转。肾脏生理和病理生理学的不同组成部分，包括肾素-血管紧张素-醛固酮系统、内皮素系统和肾小管转运体，都存在性别双态性。本综述探讨了肾功能和血压调节方面的性别差异。通过了解这些差异，我们可以深入了解管理高血压和肾脏疾病的潜在治疗目标，同时考虑到患者的性别和荷尔蒙状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Molecular Sciences Chemistry-Organic Chemistry

CiteScore

8.10

自引率

10.70%

发文量

13472

审稿时长

17.49 days

期刊介绍： The International Journal of Molecular Sciences (ISSN 1422-0067) provides an advanced forum for chemistry, molecular physics (chemical physics and physical chemistry) and molecular biology. It publishes research articles, reviews, communications and short notes. Our aim is to encourage scientists to publish their theoretical and experimental results in as much detail as possible. Therefore, there is no restriction on the length of the papers or the number of electronics supplementary files. For articles with computational results, the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material (including animated pictures, videos, interactive Excel sheets, software executables and others).