Potential Using of Resveratrol and Its Derivatives in Medicine.

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Taha Yasin Koç, Selin Doğan, Mehmet Karadayı
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引用次数: 0

Abstract

A phytoalexin polyphenolic chemical, resveratrol, can be found in a variety of foods, including cereals, peanuts, grapes, strawberries, and raspberries. It is also known that resveratrol protects the body against cardiovascular diseases as well as various types of cancer. In addition to these health issues, resveratrol is currently the subject of research since it helps treat and prevent a number of illnesses. More clinical research is needed to validate resveratrol's potential as a therapeutic agent, despite the plethora of in vitro and in vivo evidence to support this. When the literature data are evaluated, the fact that resveratrol has a therapeutic effect in these studies, but it is known to be subject to rapid metabolism despite its low bioavailability and oral absorption of approximately 75%, has directed the studies to resveratrol derivatives, especially piceatannol. Based on recent studies, 4 types of resveratrol derivatives were assessed in this work: hydroxylated compounds, methoxylated compounds, glycosides, and oligomers. Because of their advantageous bioactivities, methoxylated, hydroxylated, and halogenated derivatives have drawn the most interest among these classes. However, as a result of these studies, more studies should be conducted to better understand whether resveratrol derivatives can be recommended as therapeutic agents.

白藜芦醇及其衍生物在医学中的潜在用途。
谷物、花生、葡萄、草莓和覆盆子等多种食物中都含有一种植物多酚化学物质--白藜芦醇。人们还知道,白藜芦醇能保护人体免受心血管疾病和各种癌症的侵袭。除了这些健康问题,白藜芦醇目前还是研究的主题,因为它有助于治疗和预防多种疾病。尽管有大量的体外和体内证据支持白藜芦醇的治疗潜力,但还需要更多的临床研究来验证。在对文献数据进行评估时,发现白藜芦醇在这些研究中具有治疗效果,但尽管其生物利用率较低,口服吸收率约为 75%,但众所周知,白藜芦醇会被快速代谢,因此研究方向转向了白藜芦醇衍生物,尤其是皮萨醇。根据最近的研究,本研究评估了 4 种白藜芦醇衍生物:羟基化合物、甲氧基化合物、苷和低聚物。由于甲氧基化、羟基化和卤化衍生物具有良好的生物活性,因此在这几类衍生物中最受关注。然而,由于这些研究的结果,应该进行更多的研究,以更好地了解是否可以推荐白藜芦醇衍生物作为治疗药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Eurasian Journal of Medicine
Eurasian Journal of Medicine Medicine-Medicine (all)
CiteScore
1.90
自引率
6.70%
发文量
59
审稿时长
16 weeks
期刊介绍: Eurasian Journal of Medicine (Eurasian J Med) is an international, scientific, open access periodical published by independent, unbiased, and triple-blinded peer-review principles. The journal is the official publication of Atatürk University School of Medicine and published triannually in February, June, and October. The publication language of the journal is English. The aim of the Eurasian Journal of Medicine is to publish original research papers of the highest scientific and clinical value in all medical fields. The Eurasian J Med also includes reviews, editorial short notes and letters to the editor that either as a comment related to recently published articles in our journal or as a case report. The target audience of the journal includes researchers, physicians and healthcare professionals who are interested or working in in all medical disciplines.
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