Delayed definitive management of localized prostate cancer: what do we know?

IF 5.1 2区 医学 Q1 ONCOLOGY
Osama Mohamad, Yun Rose Li, Felix Feng, Julian C Hong, Anthony Wong, Zakaria El Kouzi, Mohamed Shelan, Thomas Zilli, Peter Carroll, Mack Roach
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引用次数: 0

Abstract

Delays in the work-up and definitive management of patients with prostate cancer are common, with logistics of additional work-up after initial prostate biopsy, specialist referrals, and psychological reasons being the most common causes of delays. During the COVID-19 pandemic and the subsequent surges, timing of definitive care delivery with surgery or radiotherapy has become a topic of significant concern for patients with prostate cancer and their providers alike. In response, recommendations for the timing of definitive management of prostate cancer with radiotherapy and radical prostatectomy were published but without a detailed rationale for these recommendations. While the COVID-19 pandemic is behind us, patients are always asking the question: "When should I start radiation or undergo surgery?" In the absence of level I evidence specifically addressing this question, we will hereby present a narrative review to summarize the available data on the effect of treatment delays on oncologic outcomes for patients with localized prostate cancer from prospective and retrospective studies.

局部前列腺癌的延迟明确治疗:我们知道些什么?
前列腺癌患者的检查和最终治疗延迟是常见现象,最常见的延迟原因包括前列腺活检后的额外检查、专家转诊和心理原因。在 COVID-19 大流行期间以及随后的激增中,手术或放疗的最终治疗时机已成为前列腺癌患者及其医疗服务提供者都非常关注的话题。为此,美国公布了前列腺癌放疗和根治性前列腺切除术明确治疗时机的建议,但没有详细说明这些建议的理由。虽然 COVID-19 大流行已经过去,但患者一直在问这个问题:"我应该什么时候开始放疗或手术?由于缺乏专门针对这一问题的 I 级证据,我们将在此提交一篇叙述性综述,总结前瞻性和回顾性研究中有关治疗延迟对局部前列腺癌患者肿瘤预后影响的现有数据。
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来源期刊
Prostate Cancer and Prostatic Diseases
Prostate Cancer and Prostatic Diseases 医学-泌尿学与肾脏学
CiteScore
10.00
自引率
6.20%
发文量
142
审稿时长
6-12 weeks
期刊介绍: Prostate Cancer and Prostatic Diseases covers all aspects of prostatic diseases, in particular prostate cancer, the subject of intensive basic and clinical research world-wide. The journal also reports on exciting new developments being made in diagnosis, surgery, radiotherapy, drug discovery and medical management. Prostate Cancer and Prostatic Diseases is of interest to surgeons, oncologists and clinicians treating patients and to those involved in research into diseases of the prostate. The journal covers the three main areas - prostate cancer, male LUTS and prostatitis. Prostate Cancer and Prostatic Diseases publishes original research articles, reviews, topical comment and critical appraisals of scientific meetings and the latest books. The journal also contains a calendar of forthcoming scientific meetings. The Editors and a distinguished Editorial Board ensure that submitted articles receive fast and efficient attention and are refereed to the highest possible scientific standard. A fast track system is available for topical articles of particular significance.
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