Celastrol: A century-long journey from the isolation to the biotechnological production and the development of an antiobesity drug

IF 8.3 2区 生物学 Q1 PLANT SCIENCES
Yong Zhao, Karel Miettinen, Sotirios C. Kampranis
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引用次数: 0

Abstract

Celastrol, a triterpenoid found in the root of the traditional medicinal plant Tripterygium wilfordii, is a potent anti-inflammatory and antiobesity agent. However, pharmacological exploitation of celastrol has been hindered by the limited accessibility of plant material, the co-existence of other toxic compounds in the same plant tissue, and the lack of an efficient chemical synthesis method. In this review, we highlight recent progress in elucidating celastrol biosynthesis and discuss how this knowledge can facilitate its scalable bioproduction using cell factories and its further development as an antiobesity and anti-inflammatory drug.

塞拉斯托尔:从分离到生物技术生产以及开发抗肥胖药物的百年历程。
Celastrol 是一种三萜类化合物,存在于传统药用植物三尖杉(Tripterygium wilfordii)的根部,是一种有效的抗炎和抗肥胖剂。然而,由于植物材料的可获取性有限、同一植物组织中同时存在其他有毒化合物以及缺乏高效的化学合成方法等原因,芹菜酚的药理开发一直受到阻碍。在这篇综述中,我们将重点介绍在阐明芹菜醇生物合成方面取得的最新进展,并讨论这些知识如何促进利用细胞工厂进行可扩展的生物生产,以及如何将其进一步开发为一种抗肥胖和抗炎药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current opinion in plant biology
Current opinion in plant biology 生物-植物科学
CiteScore
16.30
自引率
3.20%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
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