Spectral-domain OCT characteristics of intraretinal hyper-reflective foci associated with age-related macular degeneration and diabetic retinopathy.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-08-08 DOI:10.1016/j.jcjo.2024.07.017

Maryam Ashrafkhorasani, Abbas Habibi, Muneeswar Gupta Nittala, Mehdi Yaseri, Mehdi Emamverdi, Swetha Bindu Velaga, Charles C Wykoff, Thomas A Ciulla, Michael Ip, SriniVas R Sadda

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Abstract

Objective: The purpose of this study was to quantitatively analyze and compare OCT characteristics of intraretinal hyper-reflective foci (IHRF) in eyes with diabetic retinopathy (DR) versus age-related macular degeneration (AMD).

Design: a retrospective observational study.

Participants: 54 treatment-naïve eyes (27 DR and 27 AMD).

Methods: The IHRF lesions in OCT B-scan were semi-automatically segmented. Mean reflectivity (MR), maximum diameter, circularity index (Cir), area, and the angle between the greatest linear dimension (GLD) and the horizontal were computed for each IHRF lesion. The presence and absence of a posterior shadow and the axial location were assessed. The MR was normalized using the vitreous and nerve fiber layer reflectance as dark and bright reference standards, respectively.

Results: A total of 1149 IHRF (1051 in DR and 98 in the AMD group) were identified, with a mean of 39 ± 36 lesions in DR eyes compared to only 4 ± 4 in AMD eyes (p < 0.001). The mean area of individual IHRF lesions was greater in DR eyes (1305 ± 1647 μm² vs 1031 ± 750 μm²; p = 0.016), but IHRF in AMD eyes had higher reflectivity (1.17 ± 0.14 vs 1.03 ± 0.17; p < 0.001). The angle of the GLD relative to the horizontal was greater in AMD eyes, indicating that IHRF in AMD eyes were more horizontally oriented. In AMD eyes, 88.8% of IHRF were located beneath the inner border of the outer nuclear layer (ONL), while in DR eyes, 56.9% were located there (p < 0.001).

Conclusions: IHRF lesions in eyes with DR and AMD demonstrate significant differences, with IHRF in DR eyes tending to be larger and less hyper-reflective compared to AMD eyes.

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与老年性黄斑变性和糖尿病视网膜病变相关的视网膜内高反射灶的光谱域 OCT 特征。

研究目的本研究旨在定量分析和比较糖尿病视网膜病变（DR）与年龄相关性黄斑变性（AMD）患者视网膜内高反射灶（IHRF）的OCT特征：54只未经治疗的眼睛（27只为DR，27只为AMD）：对 OCT B 扫描中的 IHRF 病变进行半自动分割。计算每个 IHRF 病变的平均反射率 (MR)、最大直径、圆度指数 (Cir)、面积以及最大线性维度 (GLD) 与水平线之间的夹角。评估是否存在后方阴影以及轴向位置。分别以玻璃体和神经纤维层反射率作为暗参照标准和亮参照标准，对磁共振进行归一化处理：共发现 1149 个 IHRF（DR 组 1051 个，AMD 组 98 个），DR 眼平均为 39 ± 36 个病变，而 AMD 眼仅为 4 ± 4 个（P < 0.001）。DR 眼球中单个 IHRF 病变的平均面积更大（1305 ± 1647 μm² vs 1031 ± 750 μm²；p = 0.016），但 AMD 眼球中的 IHRF 反射率更高（1.17 ± 0.14 vs 1.03 ± 0.17；p < 0.001）。AMD眼的GLD相对于水平面的角度更大，表明AMD眼的IHRF更倾向于水平方向。在AMD眼中，88.8%的IHRF位于核外层（ONL）的内缘下方，而在DR眼中，56.9%的IHRF位于核外层（ONL）的内缘下方（P < 0.001）：结论：DR和AMD眼球中的IHRF病变存在显著差异，与AMD眼球相比，DR眼球中的IHRF往往更大，高反射程度更低。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567