A New Age of Drug Delivery: A Comparative Perspective of Ferritin-Drug Conjugates (FDCs) and Antibody-Drug Conjugates (ADCs).

IF 4 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioconjugate Chemistry Pub Date : 2024-08-21 Epub Date: 2024-08-12 DOI:10.1021/acs.bioconjchem.4c00254

Juanji Hong, Kang Li, Jiuyang He, Minmin Liang

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Abstract

Ferritin-drug conjugates (FDCs) and antibody-drug conjugates (ADCs) respectively represent the innovative and traditional mainstream approaches in drug delivery systems, each offering unique advantages and challenges. This viewpoint delves into the evolving landscape of drug delivery technologies, specifically focusing on FDCs and ADCs. Each method exhibits unique advantages and inherent challenges, shaping their roles in therapeutic applications. The article provides a comparative analysis of two delivery systems, FDCs and ADCs, in terms of targeting accuracy, drug loading capacity, and the nature of the payload itself. This comparison offers valuable insights into the distinct advantages and disadvantages associated with each system, enabling a clearer understanding of their potential applications and limitations in therapeutic contexts. This analysis is crucial for optimizing the use of these delivery systems across varying medical contexts, offering a comprehensive overview of their impact on the field of drug delivery.

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给药新时代：铁蛋白-药物共轭物 (FDC) 和抗体-药物共轭物 (ADC) 的比较视角。

铁蛋白-药物共轭物（FDCs）和抗体-药物共轭物（ADCs）分别代表了给药系统中创新和传统的主流方法，各自具有独特的优势和挑战。这一观点深入探讨了不断发展的给药技术，特别是 FDC 和 ADC。每种方法都具有独特的优势和固有的挑战，决定了它们在治疗应用中的作用。文章从靶向准确性、载药能力和有效载荷本身的性质等方面对 FDC 和 ADC 这两种给药系统进行了比较分析。通过比较，我们可以深入了解每种系统的明显优缺点，从而更清楚地了解它们在治疗方面的潜在应用和局限性。这种分析对于优化这些给药系统在不同医疗环境中的应用至关重要，并能全面概述它们对给药领域的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioconjugate Chemistry 生物-化学综合

CiteScore

9.00

自引率

2.10%

发文量

236

审稿时长

1.4 months

期刊介绍： Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.