Daniela Fodor, Oana Serban, Sergiu Gabriel Macavei, Lucian Barbu Tudoran, Paula Bora, Maria Badarinza
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引用次数: 0
Abstract
Intra-articular hyaluronic acid (HA) injections are widely used for the treatment of symptomatic knee osteoarthritis. Adverse reactions were described in a limited number of patients and consist in local inflammatory reactions and severe acute inflammatory reactions (pseudosepsis). We present the case of a 71-year-old woman who experienced a severe acute adverse effect immediately (within minutes) following intraarticular HA administration, attributed to HA precipitation. The severe very early local manifestations were accompanied by important systemic reactions, necessitating treatment with systemic corticosteroids besides joint lavage.
关节内透明质酸（HA）注射被广泛用于治疗有症状的膝关节骨关节炎。不良反应仅在少数患者中出现，包括局部炎症反应和严重急性炎症反应（假性关节炎）。我们介绍了一名 71 岁女性的病例，她在关节内注射 HA 后立即（几分钟内）出现了严重的急性不良反应，原因是 HA 沉淀。严重的早期局部表现伴随着重要的全身反应，除了关节灌洗外，还需要使用全身性皮质类固醇治疗。
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