Highly Sensitive and Selective Recognition of Zn²⁺ and Fe²⁺ Ions Using a Novel Thiophene-Derived Hydrazone Dual Fluorometric Sensor.

IF 2.6 4区化学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Fluorescence Pub Date : 2024-08-10 DOI:10.1007/s10895-024-03897-1

I Hamzi, Y Mered, B Mostefa-Kara

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Abstract

The selective detection of Zn²⁺ and Fe²⁺ ions is critical in environmental and biological studies. Schiff base chemosensors hold promise, but exploration of thiophene-derived variants remains limited. This work introduces a novel thiophene-derived Schiff base sensor (TBH), synthesized through the condensation reaction of thiophene-2-carboxaldehyde with benzil-bis-hydrazone, for the selective detection of Zn²⁺ and Fe²⁺ ions. TBH exhibits remarkable selectivity, with a significant 185-fold fluorescence enhancement for Zn²⁺ and complete quenching 99% for Fe²⁺, allowing for distinct detection of both ions. Notably, TBH demonstrates high binding affinity towards Zn²⁺ and Fe²⁺, even in the presence of competing cations, forming stable 1:1 complexes. This finding is supported by absorption and emission titration studies and FT-IR analysis as well. This easily synthesized, rapid and cost-effective sensor offers a promising approach for sensitive and differentiated dual detection of Zn²⁺ and Fe²⁺ in environmental and biological systems.

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利用新型噻吩衍生腙双荧光传感器高灵敏、高选择性地识别 Zn2⁺和 Fe2⁺离子

选择性检测 Zn2⁺和 Fe2⁺离子对环境和生物研究至关重要。希夫碱化学传感器前景广阔，但对噻吩衍生变体的探索仍然有限。本研究介绍了一种新型的噻吩衍生席夫碱传感器（TBH），它是通过噻吩-2-甲醛与苯齐双氢腙的缩合反应合成的，用于选择性检测 Zn2⁺和 Fe2⁺离子。TBH 具有显著的选择性，对 Zn2⁺的荧光增强 185 倍，而对 Fe2⁺ 的荧光完全淬灭 99%，因此可以同时检测这两种离子。值得注意的是，TBH 对 Zn2⁺ 和 Fe2⁺ 具有很高的结合亲和力，即使在存在竞争阳离子的情况下也能形成稳定的 1:1 复合物。这一发现也得到了吸收和发射滴定研究以及傅立叶变换红外分析的支持。这种易于合成、快速且具有成本效益的传感器为环境和生物系统中 Zn2⁺和 Fe2⁺的灵敏和差异化双重检测提供了一种可行的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Fluorescence 化学-分析化学

CiteScore

4.60

自引率

7.40%

发文量

203

审稿时长

5.4 months

期刊介绍： Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.