Serum fibulin-3 as a diagnostic and prognostic biomarker in patients with knee osteoarthritis.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Irish Journal of Medical Science Pub Date : 2024-12-01 Epub Date: 2024-08-11 DOI:10.1007/s11845-024-03780-9

Maria Abdullah Hassan, Areej Sh Hameed, Ekhlas Khalid Hameed

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引用次数: 0

Abstract

Background: Osteoarthritis is a chronic degenerative disorder with rising prevalence. Early detection of structural damage is difficult. Consequently, there is a pressing demand for reliable biomarkers that enable an earlier diagnosis of osteoarthritis. The aim is to investigate the level of serum fibulin-3 in patients with primary knee osteoarthritis and its correlation with disease severity.

Subjects and methods: A case-control study was conducted at the Baqubah Teaching Hospital from November 2023 to January 2024. One hundred twenty persons participated in this study (eighty females with the diagnosis of knee osteoarthritis in its early and late stages, and forty age-matched, apparently healthy control. Serum fibulin-3, ESR, CRP, and calcium levels were measured for all participants. Ethical approval was obtained. SPSS was used for data analysis.

Results: Patients with osteoarthritis had considerably higher serum levels of fibulin-3. In patients with late-stage knee osteoarthritis, this rise was greater than in earlier stages. Serum fibulin and ESR are positively correlated. Fibulin's area under the curve is 0.830 for diagnosis and 0.709 for differentiating between osteoarthritis's early and late stages.

Conclusion: Serum levels of fibulin-3 can act as diagnostic markers for OA and may be useful in determining the severity of knee osteoarthritis.

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作为膝骨关节炎患者诊断和预后生物标志物的血清纤维蛋白 3。

背景：骨关节炎是一种慢性退行性疾病，发病率呈上升趋势。结构性损伤的早期检测非常困难。因此，人们迫切需要可靠的生物标志物，以便更早地诊断骨关节炎。本研究旨在调查原发性膝骨关节炎患者血清纤维蛋白-3的水平及其与疾病严重程度的相关性：一项病例对照研究于 2023 年 11 月至 2024 年 1 月在巴古拜教学医院进行。共有 120 人参与了这项研究（其中 80 名女性被诊断出患有早期和晚期膝关节骨关节炎，另外 40 名年龄匹配、表面健康的对照组）。对所有参与者的血清纤维蛋白-3、血沉、CRP 和钙水平进行了测量。研究获得了伦理批准。数据分析采用 SPSS：结果：骨关节炎患者的血清纤维蛋白-3水平要高得多。晚期膝骨关节炎患者的血清纤维蛋白-3水平比早期更高。血清纤维蛋白与血沉呈正相关。纤维蛋白的曲线下面积在诊断时为 0.830，在区分骨关节炎早期和晚期时为 0.709：结论：血清纤维蛋白-3的水平可作为OA的诊断指标，并可用于判断膝关节骨性关节炎的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.