Model of Accelerated Aging in CB6F2 Mice Induced by Ionizing Radiation.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-10 DOI:10.1007/s10517-024-06190-0

E A Yakunchikova, M N Yurova, I S Drachyov, E A Radetskaya, K V Altukhov, A L Semenov, A V Panchenko, M L Tyndyk, V N Bykov, E I Fedoros

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引用次数: 0

Abstract

A model for accelerated aging in mice was developed: CB6F2 mice aged 39-45 days were exposed to fractionated 4-fold relatively uniform γ-radiation (¹³⁷Cs, 0.98 Gy/min) at a total dose of 6.8 Gy. Radiation exposure led to delayed active growth, leukopenia, and lymphopenia for over 1 year during the post-radiation period. The death of irradiated males and females occurred significantly earlier than in control group animals. Median lifespans in the experimental group were 35-38% lower than in the control group (p<0.001). Ionizing radiation exposure led to the early development of hair depigmentation, cachexia, and the development of aging-associated diseases. In irradiated mice, oncological pathology constituted 30-35% in the mortality structure, which is twice as often as in the control group. The developed model can be used to study the pathogenesis of accelerated aging under radiation exposure and the search for means of its prevention and treatment.

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电离辐射诱导的 CB6F2 小鼠加速衰老模型

我们建立了一个小鼠加速衰老模型：将年龄为 39-45 天的 CB6F2 小鼠暴露于分次 4 倍相对均匀的 γ 辐射（137Cs，0.98 Gy/分钟），总剂量为 6.8 Gy。在辐射后的一年多时间里，辐射照射导致活性生长延迟、白细胞减少和淋巴细胞减少。接受辐照的雄性和雌性动物的死亡时间明显早于对照组动物。实验组的中位寿命比对照组低 35-38%（p

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.