Genetic Features of Tongue Cancer Recurrence in Young Adults.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-11 DOI:10.1007/s10517-024-06189-7

E S Kolegova, A A Schegoleva, R S Vorobev, I K Fedorova, D E Kulbakin, A P Polyakov, A V Mordovsky, L P Yakovleva, A S Vyalov, V T Tsiklauri, M A Kropotov, N G Suchkova, N S Sukortseva, I V Reshetov, E L Choinzonov, E V Denisov

引用次数: 0

Abstract

To identify genetic alterations associated with tongue cancer recurrence in young adults, whole exome sequencing of the primary tumor, recurrence, and whole blood samples from young patients with tongue cancer was performed. A frameshift mutation in the TP53 gene was detected in the primary tumor and recurrence tumor tissue. A mutation in the EPHB6 gene was detected in the recurrence and was absent in the primary tumor. In addition, the primary tumor and recurrence tongue cancer tissue harbored amplification of the 20p13 region containing C20orf96, DEFB125, DEFB126, DEFB127, DEFB128, DEFB129, DEFB132, and ZCCHC3 genes. Thus, genetic alterations have been identified that are associated with tongue cancer recurrence in young adults.

查看原文本刊更多论文

年轻人舌癌复发的遗传特征

为了确定与年轻成人舌癌复发相关的基因改变，研究人员对年轻舌癌患者的原发肿瘤、复发肿瘤和全血样本进行了全外显子组测序。在原发肿瘤和复发肿瘤组织中检测到 TP53 基因的框架移位突变。在复发肿瘤中检测到 EPHB6 基因突变，而在原发肿瘤中则未发现该突变。此外，原发肿瘤和复发舌癌组织的 20p13 区域含有 C20orf96、DEFB125、DEFB126、DEFB127、DEFB128、DEFB129、DEFB132 和 ZCCHC3 基因扩增。因此，已经发现了与年轻人舌癌复发有关的基因改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.