A review on phytochemicals as combating weapon for multidrug resistance in cancer

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI:10.1080/10286020.2024.2386678

Sharwan Gupta , Anuradha Mehra , Rekha Sangwan

引用次数: 0

Abstract

One can recognize multidrug resistance (MDR) and residue as a biggest difficulty in cancer specialist. Chemotherapy-resistant cancer may be successfully treated by combining MDR-reversing phytochemicals with anticancer drugs. Though, clinical application of phytochemicals either alone or in conjunction with chemotherapy is still in its early stages or requires more research to determine their safety and efficacy. In this review we highlighted topics related to MDR in cancer, including an introduction to subject, mechanism of action of efflux pump, specific proteins involved in drug resistance, altered drug targets, increased drug metabolism, and potential role of phytochemicals in overcoming drug resistance.

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综述植物化学物质作为抗击癌症多药耐药性的武器。

多药耐药性（MDR）和残留是癌症专家面临的最大难题。通过将可逆转 MDR 的植物化学物质与抗癌药物相结合，可成功治疗耐化疗癌症。不过，植物化学物单独或与化疗结合的临床应用仍处于早期阶段，或需要更多的研究来确定其安全性和有效性。在这篇综述中，我们重点介绍了与癌症中的 MDR 相关的主题，包括该主题的介绍、外排泵的作用机制、涉及耐药性的特定蛋白质、药物靶点的改变、药物代谢的增加以及植物化学物在克服耐药性方面的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.