Cis -decalin tetramic acid metabolite from a mangrove derived endophytic fungus Nigrospora oryzae

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Antibiotics Pub Date : 2024-08-08 DOI:10.1038/s41429-024-00764-w

Antonius R. B. Ola

引用次数: 0

Abstract

Most of the natural products containing tetramic acid have trans configuration of the decalin moiety. Undana A (1), a new cis decalin-bearing tetramic acid metabolite was isolated from endophytic fungi Nigrospora oryzae associated with Avicennia marina. The structure was determined based on the mass and NMR spectral data together with the comparison of the literature. This is the first report of cis decalin-tetramic acid metabolite from the mangrove endophytic fungus. Compound 1 was tested for cytotoxic against L5178Y mouse cancer cells and antibacterial activity against several gram-positive including MRSA and gram-negative bacteria but was found inactive.

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来自红树林内生真菌 Nigrospora oryzae 的顺式癸醛四甲酸代谢物。

大多数含有四元萘酸的天然产物的萘癸酸分子都是反式构型。Undana A (1) 是一种新的顺式癸醛四酸代谢物，是从与 Avicennia marina 相关的内生真菌 Nigrospora oryzae 中分离出来的。根据质谱和核磁共振光谱数据以及文献对比确定了其结构。这是首次报道来自红树林内生真菌的顺式癸醛四甲酸代谢物。测试了化合物 1 对 L5178Y 小鼠癌细胞的细胞毒性，以及对包括 MRSA 在内的几种革兰氏阳性菌和革兰氏阴性菌的抗菌活性，结果发现化合物 1 没有活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.