Efficacy and Safety of Biologics in Polymyalgia Rheumatica: A Retrospective Study.

IF 2.9 3区医学 Q2 RHEUMATOLOGY

Rheumatology and Therapy Pub Date : 2024-10-01 Epub Date: 2024-08-09 DOI:10.1007/s40744-024-00707-9

Naoaki Ohkubo, Yusuke Miyazaki, Shingo Nakayamada, Shunsuke Fukuyo, Yoshino Inoue, Yurie Satoh-Kanda, Hiroaki Tanaka, Yasuyuki Todoroki, Hiroko Miyata, Atsushi Nagayasu, Masashi Funada, Hiroki Kobayashi, Hidenori Sakai, Shumpei Kosaka, Satsuki Matsunaga, Yukiko Tomoyose, Hirotsugu Nohara, Yoshiya Tanaka

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引用次数: 0

Abstract

Introduction: The study aimed to determine the efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) in the treatment of polymyalgia rheumatica (PMR) complicated by rheumatoid arthritis (RA).

Methods: Patients with PMR which could be classified as RA and who were treated with bDMARDs were included in the analysis. The primary endpoint was the clinical Polymyalgia Rheumatica Activity Score (Clin-PMR-AS) after 26 weeks of treatment, and the secondary endpoint was adverse events during the observation period.

Results: A total of 203 patients with PMR which was resistant or intolerant to glucocorticoids and could be classified as RA were receiving bDMARDs and were enrolled in the study. There were 83, 82, and 38 patients in the tumor necrosis factor inhibitor (TNFi), interleukin-6 receptor inhibitor (IL-6Ri), and cytotoxic T lymphocyte-associated antigen-4-immunoglobulin (CTLA4-Ig) groups, respectively. Twenty-six weeks after bDMARD initiation, Clin-PMR-AS levels were significantly lower in the IL-6Ri group as compared to other groups. Multiple regression analysis was performed with Clin-PMR-AS as the objective variable. Body mass index (BMI), history of bDMARDs, and IL-6Ri use were identified as factors involved in Clin-PMR-AS. After adjustment for group characteristics using inverse probability of treatment weighting with propensity scores, the Clin-PMR-AS score at 26 weeks was significantly lower in the IL-6Ri group (9.0) than in both the TNFi (12.4, p = 0.004) and CTLA4-Ig (15.9, p = 0.003) group.

Conclusion: IL-6Ri may potentially improve the disease activity of PMR compared to other bDMARDs.

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生物制剂对多发性风湿痛的疗效和安全性：回顾性研究

研究简介该研究旨在确定生物改良抗风湿药（bDMARDs）治疗类风湿关节炎（RA）并发多发性风湿痛（PMR）的疗效和安全性：方法：分析对象包括可归类为RA并接受bDMARDs治疗的多发性风湿痛患者。主要终点是治疗26周后的临床多发性风湿痛活动评分（Clin-PMR-AS），次要终点是观察期间的不良事件：共有203名对糖皮质激素耐药或不耐受且可归类为RA的PMR患者接受了bDMARDs治疗并被纳入研究。肿瘤坏死因子抑制剂（TNFi）组、白细胞介素-6受体抑制剂（IL-6Ri）组和细胞毒性T淋巴细胞相关抗原-4-免疫球蛋白（CTLA4-Ig）组分别有83名、82名和38名患者。开始使用 bDMARD 26 周后，IL-6Ri 组的 Clin-PMR-AS 水平明显低于其他组。以Clin-PMR-AS为目标变量进行了多元回归分析。体质指数（BMI）、bDMARDs 使用史和 IL-6Ri 的使用被认为是影响 Clin-PMR-AS 的因素。在使用倾向分数的反向治疗概率加权法对各组特征进行调整后，26周时IL-6Ri组的Clin-PMR-AS评分（9.0）显著低于TNFi组（12.4，P = 0.004）和CTLA4-Ig组（15.9，P = 0.003）：结论：与其他bDMARDs相比，IL-6Ri有可能改善PMR的疾病活动性。

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来源期刊

Rheumatology and Therapy RHEUMATOLOGY-

CiteScore

6.00

自引率

5.30%

发文量

审稿时长

6 weeks

期刊介绍： Aims and Scope Rheumatology and Therapy is an international, open access, peer reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world and health outcomes research around the discovery, development, and use of rheumatologic therapies. Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also welcomed. Areas of focus include, but are not limited to, rheumatoid arthritis, gout, gouty arthritis, psoriatic arthritis, osteoarthritis, juvenile idiopathic/rheumatoid arthritis, systemic lupus erythematosus, axial spondyloarthritis, Pompe’s disease, inflammatory joint conditions, musculoskeletal conditions, systemic sclerosis, and fibromyalgia. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, case reports, trial protocols, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Rheumatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research. Ethics and Disclosures The journal is a member of the Committee on Publication Ethics (COPE) and subscribes to its principles on how to deal with acts of misconduct thereby committing to investigate allegations of misconduct in order to ensure the integrity of research. Content in this journal is peer-reviewed (Single-blind). For more information on our publishing ethics policies, please see here: https://www.springer.com/gp/editorial-policies Rapid Publication The journal’s rapid publication timelines aim for a peer review decision within 2 weeks of submission. If an article is accepted it will be published online 3-4 weeks from acceptance. These rapid timelines are achieved through the combination of a dedicated in-house editorial team, who closely manage article workflow, and an extensive Editorial and Advisory Board who assist with rapid peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid and efficient communication of the latest research and reviews, allowing the advancement of rheumatologic therapies. 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