Systemic Inflammatory Response Index and the Short-Term Functional Outcome of Patients with Acute Ischemic Stroke: A Meta-analysis.

IF 3.9 3区医学 Q1 CLINICAL NEUROLOGY

Neurology and Therapy Pub Date : 2024-10-01 Epub Date: 2024-08-09 DOI:10.1007/s40120-024-00645-2

Ying Han, Nan Lin

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Abstract

Introduction: The systemic inflammatory response index (SIRI) is a novel indicator of systemic inflammation derived from the absolute counts of neutrophils, monocytes, and lymphocytes. The aim of this meta-analysis was to evaluate the association between SIRI and functional outcome in patients with acute ischemic stroke (AIS).

Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed in this meta-analysis. Relevant cohort studies were retrieved by a search of electronic databases including PubMed, Web of Science, Embase, Wanfang, and China National Knowledge Infrastructure from database inception to February 9, 2024. A poor functional outcome was defined as a modified Rankin Scale ≥ 3 within 3 months after disease onset. A random-effects model was used to combine the data by incorporating the influence of between-study heterogeneity. The protocol of the meta-analysis was not prospectively registered in PROSPERO.

Results: Fourteen cohort studies were included. Pooled results showed that a high SIRI at admission was associated with increased risk of poor functional outcome within 3 months (odds ratio [OR]: 1.57, 95% confidence interval: 1.39 to 1.78, p < 0.001; I² = 0%). Results of the meta-regression analysis suggested that the cutoff for defining a high SIRI was positively related to the OR for the association between SIRI and the risk of poor functional outcome (coefficient = 0.13, p = 0.03), while other variables including sample size, mean age, severity of stroke at admission, percentage of men, current smokers, or patients with diabetes did not significantly modify the results. Subgroup analyses according to study design, main treatments, and study quality scores showed similar results.

Conclusion: A high SIRI may be associated with a poor functional outcome in patients after AIS.

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全身炎症反应指数与急性缺血性脑卒中患者的短期功能预后：一项元分析

简介全身炎症反应指数（SIRI）是根据中性粒细胞、单核细胞和淋巴细胞的绝对计数得出的一种新型全身炎症指标。本荟萃分析旨在评估 SIRI 与急性缺血性脑卒中（AIS）患者功能预后之间的关系：本荟萃分析遵循《系统综述和荟萃分析首选报告项目》指南。通过检索包括 PubMed、Web of Science、Embase、万方和中国国家知识基础设施在内的电子数据库，检索了从数据库开始到 2024 年 2 月 9 日的相关队列研究。不良功能结局的定义是发病后3个月内改良Rankin量表≥3。通过纳入研究间异质性的影响，采用随机效应模型合并数据。荟萃分析方案未在PROSPERO中进行前瞻性注册：结果：共纳入 14 项队列研究。汇总结果显示，入院时 SIRI 高与 3 个月内功能预后差的风险增加有关（几率比 [OR]：1.57，95% 置信区间：1.39 至 1.78，P 2 = 0%）。元回归分析的结果表明，定义高 SIRI 的临界值与 SIRI 和不良功能预后风险之间的相关性 OR 呈正相关（系数 = 0.13，P = 0.03），而其他变量，包括样本量、平均年龄、入院时卒中严重程度、男性比例、当前吸烟者或糖尿病患者，均未对结果产生显著影响。根据研究设计、主要治疗方法和研究质量评分进行的亚组分析显示了相似的结果：结论：高SIRI可能与AIS患者功能预后不良有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology and Therapy CLINICAL NEUROLOGY-

CiteScore

5.40

自引率

8.10%

发文量

103

审稿时长

6 weeks

期刊介绍： Aims and Scope Neurology and Therapy aims to provide reliable and inclusive, rapid publication for all therapy related research for neurological indications, supporting the timely dissemination of research with a global reach, to help advance scientific discovery and support clinical practice. Neurology and Therapy is an international, open access, peer reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world and health outcomes research around the discovery, development, and use of neurological and psychiatric therapies, (also covering surgery and devices). Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also welcomed. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, case reports, trial designs, communications and letters. 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