Inflammatory Role of CCR1 in the Central Nervous System.

IF 2.2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuroimmunomodulation Pub Date : 2024-01-01 Epub Date: 2024-08-08 DOI:10.1159/000540460

Qi Tian, Ziang Yan, Yujia Guo, Zhibiao Chen, Mingchang Li

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引用次数: 0

Abstract

Background: Chemokine ligands and their corresponding receptors are essential for regulating inflammatory responses. Chemokine receptors can stimulate immune activation or inhibit/promote signaling pathways by binding to specific chemokine ligands. Among these receptors, CC chemokine receptor 1 (CCR1) is extensively studied as a G protein-linked receptor target, predominantly expressed in various leukocytes, and is considered a promising target for anti-inflammatory therapy. Furthermore, CCR1 is essential for monocyte extravasation and transportation in inflammatory conditions. Its involvement in inflammatory diseases of the central nervous system (CNS), including multiple sclerosis, Alzheimer's disease, and stroke, has been extensively studied along with its ligands. Animal models have demonstrated the beneficial effects resulting from inhibiting CCR1 or its ligands.

Summary: This review demonstrates the significance of CCR1 in CNS inflammatory diseases, the molecules implicated in the inflammatory pathway, and potential drugs or molecules for treating CNS diseases. This evidence may offer new targets or strategies for treating inflammatory CNS diseases.

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CCR1 在中枢神经系统中的炎症作用

趋化因子配体及其同源受体在调节炎症反应方面发挥着重要作用。与相应的趋化因子配体结合后，趋化因子受体可刺激免疫激活，抑制或促进信号通路。CC 趋化因子受体 1（CCR1）是一个被广泛研究的与 G 蛋白相连的受体靶点，它主要在多种白细胞中表达，被认为是自身炎症治疗的良好靶点。此外，CCR1 在炎症条件下的单核细胞外渗和转运过程中发挥着重要作用，CCR1 及其配体在一系列中枢神经系统（CNS）炎症性疾病（包括多发性硬化症、阿尔茨海默病和中风）中也得到了广泛研究。动物模型表明，抑制 CCR1 或其配体会产生有益的影响。本综述总结了 CCR1 在中枢神经系统炎症性疾病中的作用、参与炎症通路的分子以及在中枢神经系统疾病后发挥作用的相应药物或分子。这些证据可能为治疗中枢神经系统炎症性疾病提供可能的靶点或新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroimmunomodulation 医学-免疫学

CiteScore

3.60

自引率

4.20%

发文量

审稿时长

>12 weeks

期刊介绍： The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.