Unveiling the arthritis divide: Exploring treatment response and impact in late-onset vs. young-onset rheumatoid arthritis.

IF 1.8 4区医学 Q3 RHEUMATOLOGY

Modern Rheumatology Pub Date : 2024-12-25 DOI:10.1093/mr/roae069

Nariaki Hao, Hajime Ishikawa, Asami Abe, Masanori Sudo, Sayuri Takamura, Hiroshi Otani, Satoshi Ito, Kiyoshi Nakazono, Akira Murasawa

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引用次数: 0

Abstract

Objectives: The impact of osteoarthritis (OA) on the initial treatment response of rheumatoid arthritis (RA) by treat-to-target practice was compared between the patients with an onset age of ≥65 years old [late-onset RA (LORA)] and those with an onset age of <65 years old [young-onset RA (YORA)].

Methods: A retrospective study was conducted on the patients with RA, who were referred to Department of Rheumatology, Niigata Rheumatic Center without treatment between January 2021 and July 2022. Patients with grade ≥3 OA according to the Kellgren-Lawrence (K-L) classification in either the knee or hand were classified in the OA (+) group and others were in the OA (-) group. The clinical data were compared at diagnosis and 1 year after the initial treatment between the groups for 74 LORA and 59 YORA patients, respectively.

Results: One year after starting treatment in the LORA patients, the OA (+) group had poorer disease activity control and greater disability in several activities of daily living than the OA (-) group. In the YORA patients, there were no differences in activities of daily living disability between the groups.

Conclusions: In the initial treatment of the LORA patients, the prevalence of OA was high, and the impact of OA on LORA was larger than on YORA.

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揭开关节炎鸿沟的面纱：探索晚发型与年轻发型类风湿关节炎的治疗反应和影响。

研究目的比较发病年龄≥65岁（晚发 RA [LORA]）和发病年龄≥65岁的类风湿关节炎（RA）患者之间骨关节炎（OA）对目标治疗（T2T）初始治疗反应的影响：对2021年1月至2022年7月期间转诊至本诊所且未接受治疗的RA患者进行回顾性研究。根据凯尔格伦-劳伦斯（Kellgren-Lawrence，K-L）分类法，膝关节或手部OA≥3级的患者被归入OA（+）组，其他患者被归入OA（-）组。分别比较了 74 名 LORA 和 59 名 YORA 患者诊断时和首次治疗一年后的临床数据：结果：与 OA（-）组相比，OA（+）组患者在开始治疗一年后的疾病活动控制较差，在几项日常生活活动（ADL）中的残疾程度较高。在YORA患者中，各组之间的ADL残疾程度没有差异：结论：在LORA患者的初始治疗中，OA的发病率较高，OA对LORA的影响大于对YORA的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Modern Rheumatology RHEUMATOLOGY-

CiteScore

4.90

自引率

9.10%

发文量

146

审稿时长

1.5 months

期刊介绍： Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions