Assessing the efficacy of haemoperfusion for dermatomyositis-associated acute exacerbation of interstitial lung disease: A multicentre retrospective study.

IF 1.8 4区医学 Q3 RHEUMATOLOGY

Modern Rheumatology Pub Date : 2025-02-21 DOI:10.1093/mr/roae066

Shuqin Sun, Yanfei Yu, Wenjing Feng, Luyan Sun, Shuo Yang

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引用次数: 0

Abstract

Objectives: Haemoperfusion (HP) is used to treat various diseases, including sepsis and acute respiratory distress syndrome. However, few studies have explored the efficiency of HP in dermatomyositis-associated acute exacerbation of interstitial lung disease.

Methods: We conducted a retrospective study. Two hundred and sixteen patients with dermatomyositis-associated acute exacerbation of interstitial lung disease were included. Patients were divided into the HP group (treatment group) and the control group. Changes in oxygenation, haemodynamic parameters, lung ultrasound scores, and inflammatory cytokine levels were evaluated before and after HP in the treatment group. The length of intensive care unit (ICU) stays, duration of ventilator therapy, mortality rate, and incidence of complications were compared between the treatment and control groups.

Results: Haemodynamic and oxygenation variables in the treatment group significantly improved after treatment. However, the levels of the inflammatory factors significantly decreased after treatment. The length of ICU stay and the duration of ventilator therapy were significantly shorter in the treatment group than in the control group. The mortality rate of the treatment group was significantly lower than that of the control group.

Conclusions: This study demonstrated that HP could improve treatment efficacy in patients with dermatomyositis-associated acute exacerbation of interstitial lung disease.

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评估血液灌流治疗皮肌炎相关间质性肺炎急性加重的疗效：一项多中心回顾性研究。

目的：血液灌流（HP）可用于治疗多种疾病，包括败血症和急性呼吸窘迫综合征。然而，很少有研究探讨血液灌流在皮肌炎相关间质性肺病急性加重期的治疗效果：我们进行了一项回顾性研究。方法：我们进行了一项回顾性研究，纳入了 216 名皮肌炎相关间质性肺病急性加重期患者。患者被分为 HP 组（治疗组）和对照组。评估了治疗组在HP治疗前后氧合、血液动力学参数、肺部超声评分和炎症细胞因子水平的变化。比较了治疗组和对照组的重症监护室（ICU）住院时间、呼吸机治疗时间、死亡率和并发症发生率：结果：治疗组的血流动力学和氧合变量在治疗后明显改善。结果：治疗组的血流动力学和氧合变量在治疗后明显改善，但炎症因子水平在治疗后明显下降。治疗组的重症监护室住院时间和呼吸机治疗时间明显短于对照组。治疗组的死亡率明显低于对照组：本研究表明，惠普能提高皮肌炎相关间质性肺疾病急性加重期患者的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Modern Rheumatology RHEUMATOLOGY-

CiteScore

4.90

自引率

9.10%

发文量

146

审稿时长

1.5 months

期刊介绍： Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions