The role of nemolizumab in the treatment of atopic dermatitis for the adult population.

IF 2.7 4区医学 Q3 IMMUNOLOGY

Immunotherapy Pub Date : 2024-08-09 DOI:10.1080/1750743X.2024.2383554

Stuti Prajapati, Joseph P Flemming, Danyaal Khan, Haowei Han, Brian How, Suzanne Sirota Rozenberg, Steven R Feldman

引用次数: 0

Abstract

Atopic dermatitis (AD) often requires long-term treatment that may be associated with adverse effects. This review aims to characterize nemolizumab as a treatment for AD in adults. A literature search was performed to assess nemolizumab's role in moderate-to-severe AD in adults. Currently, clinical trials are being conducted to evaluate the clinical efficacy, safety profile and optimal dosing of nemolizumab for adults with moderate-to-severe AD. The most common adverse effects include nasopharyngitis, AD exacerbation and increased blood creatinine phosphokinase. Recent data from clinical trials suggest nemolizumab may be an acceptable treatment in adults with moderate-to-severe AD.

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奈莫利单抗在成人特应性皮炎治疗中的作用。

特应性皮炎（AD）通常需要长期治疗，而长期治疗可能会产生不良反应。本综述旨在描述奈莫珠单抗作为成人特应性皮炎治疗药物的特点。我们进行了文献检索，以评估奈莫珠单抗在中重度成人特应性皮炎中的作用。目前，正在进行临床试验，以评估奈莫珠单抗治疗中重度成人注意力缺失症的临床疗效、安全性和最佳剂量。最常见的不良反应包括鼻咽炎、AD 恶化和血肌酐磷酸激酶升高。最近的临床试验数据表明，尼妥珠单抗可能是一种可接受的治疗中重度AD成人患者的药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunotherapy 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

113

审稿时长

6-12 weeks

期刊介绍： Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.