Rewinding the Tape to Identify Intrinsic Determinants of Reprogramming Potential.

IF 1.2 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Cellular reprogramming Pub Date : 2024-08-01 Epub Date: 2024-08-08 DOI:10.1089/cell.2024.0035

Kate E Galloway

引用次数: 0

Abstract

Via retrospective isolation of clones using Rewind, Jain et al. identified primed states of cells that reprogram to induced pluripotent stem cells. Examining clones, they find that cells retain memory of over several rounds of cell division. Moreover, they show that extrinsic factors change the number of primed cells, suggesting that there exist diverse paths of reprogramming and states of priming.

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倒带以确定重编程潜能的内在决定因素。

通过使用 "倒带"（Rewind）技术对克隆进行回顾性分离，Jain等人确定了细胞的原始状态，这些细胞可重新编程为诱导多能干细胞。通过克隆检查，他们发现细胞在几轮细胞分裂后仍能保持记忆。此外，他们还发现外在因素会改变原始细胞的数量，这表明存在多种重编程路径和原始状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular reprogramming CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

2.50

自引率

6.20%

发文量

审稿时长

3 months

期刊介绍： Cellular Reprogramming is the premier journal dedicated to providing new insights on the etiology, development, and potential treatment of various diseases through reprogramming cellular mechanisms. The Journal delivers information on cutting-edge techniques and the latest high-quality research and discoveries that are transforming biomedical research. Cellular Reprogramming coverage includes: Somatic cell nuclear transfer and reprogramming in early embryos Embryonic stem cells Nuclear transfer stem cells (stem cells derived from nuclear transfer embryos) Generation of induced pluripotent stem (iPS) cells and/or potential for cell-based therapies Epigenetics Adult stem cells and pluripotency.