Development of the Brazilian version of the Mini-Addenbrooke Cognitive Examination (M-ACE BR) to screen for cognitive impairment in older adults.

IF 1 4区医学 Q4 NEUROSCIENCES

Arquivos de neuro-psiquiatria Pub Date : 2024-08-01 Epub Date: 2024-08-08 DOI:10.1055/s-0044-1788585

Maira Okada-Oliveira, Maria Teresa Carthery-Goulart, Karolina Gouveia César-Freitas, Ricardo Nitrini, Sonia Maria Dozzi Brucki

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引用次数: 0

Abstract

Background: Age is the most important risk factor for develop dementia, and the recommendation is that older adults are cognitively tested to detect impairment in the initial stage for adequate treatment. The demand for the care of these older adults is great, drawing attention to the need for rapid tests, with good accuracy and simple application to identify cognitive impairment.

Objective: To develop and validate the Brazilian Mini-Addenbrooke Cognitive Examination (M-ACE BR) as a short screening test for cognitive impairment in older adults.

Methods: The M-ACE BR was developed using the Mokken scaling analysis in 352 participants (cognitively unimpaired [CU] = 232, cognitive impairment no dementia [CIND] = 82; and dementia = 38) and validated in an independent sample of 117 participants (CU = 25; CIND = 88; and dementia = 4).

Results: The Mokken scaling analysis derived 9 items (spatial orientation, anterograde memory, retrograde memory, delayed recall, recognition [name and address], letter verbal fluency, repetition of 4 words, naming of 10 items, and comprehension) with a maximum score of 51 points and an average duration time of 7 minutes. The cut-off score ≤ 43/51 for CIND had a sensitivity of 59.09% and a specificity of 80%. For a screening test in which sensitivity is prioritized for further investigation, we suggest using a cutoff of ≤ 47 (sensitivity 85.23% and specificity 24%), maintaining a good positive predictive value (79.8%).

Conclusion: The M-ACE BR is a brief and adequate instrument to detect cognitive impairment in older Brazilian adults. However, screening for CIND and for different educational levels should be further explored.

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开发巴西版迷你艾登布鲁克认知检查（M-ACE BR），用于筛查老年人的认知障碍。

背景：年龄是患痴呆症的最重要的风险因素，建议对老年人进行认知测试，以便在初期阶段发现认知障碍，进行适当治疗。对这些老年人的护理需求很大，因此需要快速、准确、简单的测试来识别认知障碍：目的：开发并验证巴西阿登布鲁克认知检查（Mini-Addenbrooke Cognitive Examination，M-ACE BR），将其作为筛查老年人认知障碍的简易测试方法：M-ACE BR是在352名参与者（认知功能未受损[CU]=232人，认知功能受损无痴呆[CIND]=82人，痴呆=38人）中使用莫肯缩放分析法开发的，并在117名参与者（认知功能受损=25人，认知功能受损无痴呆=88人，痴呆=4人）的独立样本中进行了验证：莫肯缩放分析法得出了 9 个项目（空间定向、前向记忆、逆向记忆、延迟回忆、识别[姓名和地址]、字母语言流畅性、4 个单词的复述、10 个项目的命名和理解），最高分为 51 分，平均持续时间为 7 分钟。CIND 临界分数≤ 43/51 的灵敏度为 59.09%，特异度为 80%。对于灵敏度优先的筛查试验，我们建议使用≤47的临界值（灵敏度85.23%，特异性24%），同时保持良好的阳性预测值（79.8%）：结论：M-ACE BR 是检测巴西老年人认知功能障碍的简短而适当的工具。结论：M-ACE BR 是检测巴西老年人认知功能障碍的简短而适当的工具，但还应进一步探索对 CIND 和不同教育水平的筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos de neuro-psiquiatria 医学-精神病学

CiteScore

2.10

自引率

7.10%

发文量

262

审稿时长

4-8 weeks

期刊介绍： Arquivos de Neuro-Psiquiatria is the official journal of the Brazilian Academy of Neurology. The mission of the journal is to provide neurologists, specialists and researchers in Neurology and related fields with open access to original articles (clinical and translational research), editorials, reviews, historical papers, neuroimages and letters about published manuscripts. It also publishes the consensus and guidelines on Neurology, as well as educational and scientific material from the different scientific departments of the Brazilian Academy of Neurology. The ultimate goals of the journal are to contribute to advance knowledge in the areas of Neurology and Neuroscience, and to provide valuable material for training and continuing education for neurologists and other health professionals working in the area. These goals might contribute to improving care for patients with neurological diseases. We aim to be the best Neuroscience journal in Latin America within the peer review system.