Revealing the molecular mechanisms in wound healing and the effects of different physiological factors including diabetes, age, and stress

IF 2.9 4区生物学 Q3 CELL BIOLOGY

Journal of Molecular Histology Pub Date : 2024-08-09 DOI:10.1007/s10735-024-10223-3

Muhammad Summer, Shaukat Ali, Umaima Fiaz, Tauqeer Hussain, Rana Rashad Mahmood Khan, Hashim Fiaz

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引用次数: 0

Abstract

Wounds are the common fates in various microbial infections and physical damages including accidents, surgery, and burns. In response, a healthy body with a potent immune system heals that particular site within optimal time by following the coagulation, inflammation, proliferation, and remodeling phenomenon. However, certain malfunctions in the body due to various diseases particularly diabetes and other physiological factors like age, stress, etc., prolong the process of wound healing through various mechanisms including the Akt, Polyol, and Hexosamine pathways. The current review thoroughly explains the wound types, normal wound healing mechanisms, and the immune system’s role. Moreover, the mechanistic role of diabetes is also elaborated comprehensively.

Graphical abstract

Comparative analysis of the molecular events during different wound healing phases in healthy and diabetic/stressed/aged individuals.

Abstract Image

查看原文本刊更多论文

揭示伤口愈合的分子机制以及糖尿病、年龄和压力等不同生理因素的影响。

伤口是各种微生物感染和身体损伤（包括事故、手术和烧伤）的常见宿命。对此，拥有强大免疫系统的健康人体会通过凝固、炎症、增殖和重塑现象，在最佳时间内愈合特定部位的伤口。然而，由于各种疾病（尤其是糖尿病）和其他生理因素（如年龄、压力等）导致的身体机能失调，会通过各种机制（包括 Akt、多元醇和六胺途径）延长伤口愈合过程。本综述全面阐述了伤口类型、正常伤口愈合机制以及免疫系统的作用。此外，还全面阐述了糖尿病的机理作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Histology 生物-细胞生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Molecular Histology publishes results of original research on the localization and expression of molecules in animal cells, tissues and organs. Coverage includes studies describing novel cellular or ultrastructural distributions of molecules which provide insight into biochemical or physiological function, development, histologic structure and disease processes. Major research themes of particular interest include: - Cell-Cell and Cell-Matrix Interactions; - Connective Tissues; - Development and Disease; - Neuroscience. Please note that the Journal of Molecular Histology does not consider manuscripts dealing with the application of immunological or other probes on non-standard laboratory animal models unless the results are clearly of significant and general biological importance. The Journal of Molecular Histology publishes full-length original research papers, review articles, short communications and letters to the editors. All manuscripts are typically reviewed by two independent referees. The Journal of Molecular Histology is a continuation of The Histochemical Journal.