Refining the role of N6-methyladenosine in cancer

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2024-08-06 DOI:10.1016/j.gde.2024.102242

Jonas Koch, Frank Lyko

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引用次数: 0

Abstract

N⁶-methyladenosine (m⁶A) is the most abundant internal modification of eukaryotic mRNAs. m⁶A affects the fate of its targets in all aspects of the mRNA life cycle and has important roles in various physiological and pathophysiological processes. Aberrant m⁶A patterns have been observed in numerous cancers and appear closely linked to oncogenic phenotypes. However, most studies relied on antibody-dependent modification detection, which is known to suffer from important limitations. Novel, antibody-independent, quantitative approaches will be critical to investigate changes in the m⁶A landscape of cancers. Furthermore, pharmaceutical targeting of the m⁶A writer Methyltransferase-like 3 (METTL3) has demonstrated the potential to modulate cancer cell phenotypes. However, the enzyme also appears to be essential for the viability of healthy cells. Further refinement of therapeutic strategies is therefore needed to fully realize the potential of m⁶A-related cancer therapies.

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完善 N6-甲基腺苷在癌症中的作用。

N6-甲基腺苷（m6A）是真核 mRNA 最丰富的内部修饰。m6A 在 mRNA 生命周期的各个方面影响其靶标的命运，并在各种生理和病理生理过程中发挥重要作用。在许多癌症中都观察到了异常的 m6A 模式，而且似乎与致癌表型密切相关。然而，大多数研究都依赖于抗体依赖性修饰检测，众所周知，这种方法有很大的局限性。新颖的、不依赖抗体的定量方法对于研究癌症 m6A 结构的变化至关重要。此外，药物靶向 m6A 作家甲基转移酶样 3（METTL3）已被证明具有调节癌细胞表型的潜力。然而，这种酶似乎对健康细胞的存活也至关重要。因此，需要进一步完善治疗策略，以充分发挥 m6A 相关癌症疗法的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)