The Relationship Between Polychlorinated and Polybrominated Biphenyls and Glycated Hemoglobin among Electronics Workers.

IF 0.8 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Hebatalla M Aly, Reham B Ibraheem, Reem M Mahmoud, Ahmed Ismail, Sarah M Hussein
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引用次数: 0

Abstract

Background: Polychlorinated biphenyls (PCBs) are persistent organic pollutants classified as endocrine disruptors related to prediabetes and diabetes. Polybrominated biphenyls are similar in structure to PCBs and are used as flame retardants. Due to the increased worldwide prevalence of diabetes, there is increased interest in understanding the role of environmental and occupational pollutants in its development. The study aims to assess the relation between PCBs and PBBs in the serum of electronic workers and glycated hemoglobin level as an early indicator of prediabetes and type 2 diabetes mellitus among occupationally exposed workers.

Methods: Blood samples were collected from 152 workers to assess PCBs (by GCMS), random blood sugar (RBS), and glycated hemoglobin (HbA1c). Participants were classified into two groups according to the presence or absence of PCBs in their serum and were compared for RBS and HbA1c levels.

Results: Only two participants had detectable PCB derivate in their serum by GCMS, PCB 1 with methyl and benzole side chains. Regarding PBBs, 18 participants (12%) had detectable PBBs in their serum by GCMS. All participants had RBS and HbA1c levels within the normal range. No statistically significant difference was found between mean levels of RBS and HbA1c between participants with detected biphenyls and those without.

Conclusion: The banning of PCB use in industry and modern automated techniques have prevented exposure to PCBs among electronics workers. However, exposure to PBBs continues in electronic industries, but it has no association with diabetes or prediabetes.

电子工人中多氯联苯和多溴联苯与糖化血红蛋白之间的关系。
背景:多氯联苯(PCB)是一种持久性有机污染物,被归类为与糖尿病前期和糖尿病有关的内分泌干扰物。多溴联苯的结构与多氯联苯相似,被用作阻燃剂。由于糖尿病在全球的发病率越来越高,人们越来越有兴趣了解环境和职业污染物在糖尿病发病中的作用。本研究旨在评估电子工人血清中的多氯联苯和多溴联苯与糖化血红蛋白水平之间的关系,糖化血红蛋白水平是职业暴露工人中糖尿病前期和 2 型糖尿病的早期指标:收集了 152 名工人的血样,以评估多氯联苯(通过 GCMS)、随机血糖 (RBS) 和糖化血红蛋白 (HbA1c)。根据血清中是否含有多氯联苯将参与者分为两组,并对 RBS 和 HbA1c 水平进行比较:结果:通过 GCMS 检测,只有两名参与者的血清中检测到多氯联苯衍生物,即带有甲基和苯甲醚侧链的多氯联苯 1。至于多溴联苯,18 名参与者(12%)的血清中可通过气相色谱法检测到多溴联苯。所有参与者的 RBS 和 HbA1c 水平均在正常范围内。在检测到联苯和未检测到联苯的参与者之间,RBS 和 HbA1c 的平均水平没有明显的统计学差异:结论:禁止在工业中使用多氯联苯和现代自动化技术防止了电子工人接触多氯联苯。结论:禁止在工业中使用多氯联苯和现代自动化技术防止了电子工人接触多氯联苯,但电子工业中仍然存在接触多溴联苯的情况,但这与糖尿病或糖尿病前期没有关系。
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来源期刊
Indian Journal of Occupational and Environmental Medicine
Indian Journal of Occupational and Environmental Medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
1.60
自引率
0.00%
发文量
25
期刊介绍: The website of Indian Journal of Occupational and Environmental Medicine aims to make the printed version of the journal available to the scientific community on the web. The site is purely for educational purpose of the medical community. The site does not cater to the needs of individual patients and is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her existing physician.
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