Prevention of Ovarian Cancer: Where are We Now and Where are We Going?

IF 4.7 2区医学 Q1 ONCOLOGY

Current Oncology Reports Pub Date : 2024-11-01 Epub Date: 2024-08-08 DOI:10.1007/s11912-024-01587-6

Isabel V Rodriguez, Talayeh Ghezelayagh, Kathryn P Pennington, Barbara M Norquist

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Abstract

Purpose of review: To describe current and future strategies to reduce the burden of ovarian cancer through prevention.

Recent findings: Current strategies in genetic testing are missing a substantial number of individuals at risk, representing a missed opportunity for ovarian cancer prevention. Past efforts at screening and early detection have thus far failed to improve ovarian cancer mortality, and novel techniques are needed. Surgical prevention is highly effective, but surgical menopause from oophorectomy has significant side effects. Novel surgical strategies aimed at reducing risk while minimizing these harms are currently being studied. To maximize ovarian cancer prevention, a multi-pronged approach is needed. We propose that more inclusive and accurate genetic testing to identify more individuals at risk, novel molecular screening and early detection, surgical prevention that maximizes quality of life while reducing risk, and broader adoption of targeted and opportunistic salpingectomy will together reduce the burden of ovarian cancer.

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预防卵巢癌：我们的现状和未来？

综述的目的：描述当前和未来通过预防减轻卵巢癌负担的策略：目前的基因检测策略遗漏了大量高危人群，错失了预防卵巢癌的良机。过去的筛查和早期检测工作至今未能改善卵巢癌的死亡率，因此需要新的技术。手术预防非常有效，但因输卵管切除术而进行的手术绝经有很大的副作用。目前正在研究新的手术策略，旨在降低风险的同时将这些危害降到最低。为了最大限度地预防卵巢癌，需要采取多管齐下的方法。我们建议进行更全面、更准确的基因检测，以确定更多的高危人群；进行新型分子筛查和早期检测；进行手术预防，在降低风险的同时最大限度地提高生活质量；以及更广泛地采用有针对性的卵巢切除术和机会性卵巢切除术，这些措施将共同减轻卵巢癌的负担。

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来源期刊

Current Oncology Reports ONCOLOGY-

CiteScore

8.50

自引率

0.00%

发文量

187

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.