Prevalence and genotype distribution of human papillomavirus infection among 66000 women from 2014 to 2023 in the plateau region of Southwest China.

IF 4 3区 医学 Q2 VIROLOGY
Jian-Peng Hu, Jun-Ling Wang, Yun Li, Yuan Feng, Can-Qiong Tian, Guo-Hui Zhang, Xue-Qin Chen, Hong-Xia Liu, Jin-Si Yang, Zhe-Wei Fang, Yao-Xing Li, Zong-Sheng Wu, Rui Zhu, Xiu-Ping Li, Qian Xiong, Lian-Hao Gao, Ting Ji, Jian-Dong Zhang, Jian-Mei Song, Qi Chen, Shu-Min Li, Fei He, Chun-Ju Yang, Hong-Wei Li
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引用次数: 0

Abstract

Background: Persistent infection with high-risk human papillomavirus (HR-HPV) plays a key role in the onset of cervical cancer. This study was designed to examine the epidemiological trends and genotype distribution of HPV from 2014 to 2023 in the plateau region of Southwest China.

Methods: The findings could offer valuable insights for clinical screening of cervical cancer and the formulation of HPV vaccination policies. This retrospective study analyzed 66,000 women who received HPV-DNA testing at the First People's Hospital of Qujing, Yunnan, China, between 2014 and 2023. The cohort consisted of 33,512 outpatients, 3,816 inpatients, and 28,672 individuals undergoing health examinations. Cervical cells were collected for DNA extraction, and PCR amplification along with Luminex xMAP technology were used to detect 27 HPV genotypes. The data analysis was conducted using GraphPad Prism and IBM SPSS Statistics 27 software.

Results: The overall HPV infection rate at the First People's Hospital of Qujing declined from 24.92% in 2014 to 16.29% in 2023, averaging 16.02%. Specific infection rates were 18.50% among outpatients, 12.97% among inpatients, and 13.53% for health examination attendees. The predominant high-risk HPV genotypes identified were HPV52 (2.61%), HPV16 (2.06%), HPV58 (1.81%), HPV53 (1.55%), and HPV39 (1.09%). Meanwhile, the most frequent low-risk HPV genotypes were HPV6 (1.30%), HPV61 (1.21%), and HPV11 (0.85%). In HPV-positive cases, the distribution of single, double, triple, and quadruple or more infections were 79.90%, 15.17%, 3.59%, and 1.33%, respectively. The proportions of pure LR-HPV, pure HR-HPV, and mixed infections were 22.16%, 67.82%, and 10.02%, respectively. Age-specific analysis revealed a bimodal distribution of HPV infection, with the infection rate rapidly decreasing from 44.02% in the ≤ 19 age group to 19.55% in the 20-29 age group and 13.84% in the 30-39 age group, followed by a gradual increase to 14.64% in the 40-49 age group, 16.65% in the 50-59 age group, and 22.98% in the ≥ 60 age group. The coverage rates of the three available vaccines are all below 50%. The results of this study indicated a declining trend in HPV prevalence in the plateau region of Southwest China over the period from 2014 to 2023, especially in the reduction of genotypes targeted by vaccines.

Conclusion: There were significant variations in the genotypes prevalent among different age groups, years, and patient sources within the same region. The underwhelming vaccination rates emphasize the critical need for developing either a multivalent vaccine or a personalized vaccine that targets the HPV genotypes common in the Chinese population. Furthermore, vaccinating adolescents to curb HPV infection and ensuring regular cervical cancer screenings for postmenopausal women are crucial steps.

2014年至2023年中国西南高原地区66000名女性中人类乳头瘤病毒感染的流行率和基因型分布。
背景:高危人乳头瘤病毒(HR-HPV)的持续感染是宫颈癌发病的关键因素。本研究旨在探讨2014年至2023年中国西南高原地区HPV的流行趋势和基因型分布:研究结果可为宫颈癌的临床筛查和HPV疫苗接种政策的制定提供有价值的见解。这项回顾性研究分析了2014年至2023年期间在中国云南省曲靖市第一人民医院接受HPV-DNA检测的66000名女性。研究对象包括 33,512 名门诊患者、3,816 名住院患者和 28,672 名健康体检者。研究人员采集了宫颈细胞进行 DNA 提取,并利用 PCR 扩增和 Luminex xMAP 技术检测了 27 种 HPV 基因型。数据分析采用 GraphPad Prism 和 IBM SPSS Statistics 27 软件进行:曲靖市第一人民医院的HPV总体感染率从2014年的24.92%下降到2023年的16.29%,平均为16.02%。门诊患者的具体感染率为18.50%,住院患者为12.97%,体检者为13.53%。已发现的主要高危 HPV 基因型为 HPV52(2.61%)、HPV16(2.06%)、HPV58(1.81%)、HPV53(1.55%)和 HPV39(1.09%)。同时,最常见的低风险 HPV 基因型是 HPV6(1.30%)、HPV61(1.21%)和 HPV11(0.85%)。在 HPV 阳性病例中,单倍、双倍、三倍和四倍或更多感染的分布比例分别为 79.90%、15.17%、3.59% 和 1.33%。纯LR-HPV、纯HR-HPV和混合感染的比例分别为22.16%、67.82%和10.02%。年龄特异性分析显示,HPV 感染呈双峰分布,感染率从≤19 岁年龄组的 44.02% 迅速下降到 20-29 岁年龄组的 19.55% 和 30-39 岁年龄组的 13.84%,随后逐渐上升到 40-49 岁年龄组的 14.64%、50-59 岁年龄组的 16.65% 和≥60 岁年龄组的 22.98%。三种现有疫苗的覆盖率均低于 50%。研究结果表明,从2014年到2023年,中国西南高原地区的HPV感染率呈下降趋势,尤其是疫苗所针对的基因型有所减少:结论:同一地区不同年龄段、不同年份、不同患者来源的流行基因型存在明显差异。疫苗接种率不高突出表明,亟需开发针对中国人群常见 HPV 基因型的多价疫苗或个性化疫苗。此外,为青少年接种疫苗以遏制人乳头瘤病毒感染,并确保绝经后妇女定期接受宫颈癌筛查也是至关重要的步骤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Virology Journal
Virology Journal 医学-病毒学
CiteScore
7.40
自引率
2.10%
发文量
186
审稿时长
1 months
期刊介绍: Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.
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