Hyperuricemia in Cardiac Rehabilitation Patients: Prevalence and Association with Functional Improvement and Left Ventricular Ejection Fraction.

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE

High Blood Pressure & Cardiovascular Prevention Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI:10.1007/s40292-024-00665-x

Matteo Fortuna, Chiara Tognola, Michela Algeri, Atea Shkodra, Rita Cristina Myriam Intravaia, Stefano Pezzoli, Ilaria Garofani, Martina Morelli, Elena Gualini, Saverio Fabbri, Luciana Sciume, Salvatore Riccobono, Giovanna Beretta, Cristina Giannattasio, Alessandro Maloberti

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引用次数: 0

Abstract

Introduction: The role of uric acid (UA) and Hyper Uricemia (HU) in cardiac rehabilitation (CR) patients have been very little studied.

Aim: To evaluate the prevalence of HU and if it is associated to the functional improvement obtained or the left ventricular Ejection Fraction (EF) in CR patients after Acute or Chronic Coronary Syndrome (ACS and CCS respectively).

Methods: We enrol 411 patients (62.4 ± 10.2 years; males 79.8%) enrolled in the CR program at Niguarda Hospital (Milan) from January 2012 to May 2023. HU was defined both as the classic cut-off (> 6 for females, > 7 mg/dL for males) and with the newly identified one by the URRAH study (> 5.1 for females, > 5.6 mg/dL for males). All patients performed a 6MWT and an echocardiography at the beginning and at the end of CR program.

Results: Mean UA values were within the normal range (5.6 ± 1.4 mg/dL) with 19.5% (classic cut-off) HU patients with an increase to 47.4% with the newer one. Linear regression analysis showed no role for UA in determining functional improvement, while UA and hyperuricemia (classic cut-off) were associated to admission and discharge EF. The same was not with the URRAH cut-off.

Conclusions: HU is as frequent in CR patients as in those with ACS and CCS. UA didn't correlate with functional recovery while it is associated with admission and discharge EF as also is for HU (classic cut-off). Whit the URRAH cut-off HU prevalence increases significantly, however, it doesn't show any significant association with EF.

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心脏康复患者的高尿酸血症：高尿酸血症在心脏康复患者中的发病率及其与功能改善和左心室射血分数的关系

导言：目的：评估尿酸（UA）和高尿酸血症（HU）在心脏康复（CR）患者中的患病率，以及是否与急性或慢性冠状动脉综合征（分别为 ACS 和 CCS）后 CR 患者获得的功能改善或左心室射血分数（EF）有关：我们招募了 411 名患者（62.4 ± 10.2 岁；男性占 79.8%），这些患者于 2012 年 1 月至 2023 年 5 月期间加入了米兰 Niguarda 医院的 CR 项目。HU的定义既包括传统的临界值（女性>6，男性>7 mg/dL），也包括URRAH研究新确定的临界值（女性>5.1，男性>5.6 mg/dL）。所有患者在 CR 项目开始和结束时都进行了 6MWT 和超声心动图检查：平均尿酸值在正常范围内（5.6 ± 1.4 mg/dL）的 HU 患者占 19.5%（传统临界值），而新临界值则增加到 47.4%。线性回归分析表明，尿酸在决定功能改善方面没有作用，而尿酸和高尿酸血症（传统截断值）与入院和出院时的 EF 值相关。结论：结论：高尿酸血症在CR患者和ACS及CCS患者中同样常见。UA 与功能恢复无关，但与入院和出院 EF 相关，HU 也是如此（经典临界值）。当URRAH临界值升高时，HU患病率显著增加，但与EF没有明显关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

High Blood Pressure & Cardiovascular Prevention PERIPHERAL VASCULAR DISEASE-

CiteScore

5.70

自引率

3.30%

发文量

期刊介绍： High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes: Invited ''State of the Art'' reviews. Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.