The potential role of Akkermansia muciniphila in liver health.

IF 2.5 4区 生物学 Q3 MICROBIOLOGY
Future microbiology Pub Date : 2024-08-12 Epub Date: 2024-08-07 DOI:10.2217/fmb-2023-0220
Min Zhang, Yang Wang, Yong Gan
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引用次数: 0

Abstract

Akkermansia muciniphila (A. muciniphila) is a 'star strain' that has attracted much attention in recent years. A. muciniphila can effectively regulate host metabolism, significantly affect host immune function, and play an important role in balancing host health and disease. As one of the organs most closely related to the gut (the two can communicate through the hepatic portal vein and bile duct system), liver is widely affected by intestinal microorganisms. A growing body of evidence suggests that A. muciniphila may alleviate liver-related diseases by improving the intestinal barrier, energy metabolism and regulating inflammation through its protein components and metabolites. This paper systematically reviews the key roles of A. muciniphila and its derivatives in maintaining liver health and improving liver disease.

Akkermansia muciniphila 对肝脏健康的潜在作用。
Akkermansia muciniphila(A. muciniphila)是近年来备受关注的 "明星菌株"。粘菌能有效调节宿主的新陈代谢,显著影响宿主的免疫功能,在平衡宿主健康和疾病方面发挥着重要作用。作为与肠道关系最密切的器官之一(两者可通过肝门静脉和胆管系统进行沟通),肝脏受到肠道微生物的广泛影响。越来越多的证据表明,粘多糖可以通过其蛋白质成分和代谢产物改善肠道屏障、能量代谢和调节炎症,从而缓解与肝脏有关的疾病。本文系统回顾了粘菌素及其衍生物在维持肝脏健康和改善肝病方面的关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Future microbiology
Future microbiology 生物-微生物学
CiteScore
4.90
自引率
3.20%
发文量
134
审稿时长
6-12 weeks
期刊介绍: Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.
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