Exosomal CircRNAs: A Future Star in Colorectal Cancer.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-08-06 DOI:10.2174/0115680096323472240710101854

Yuanzhi Zhou, Chengyan Wei, Yuqi Xu, Jingjing Wang, Chunwei Zhang, Yong Jin

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Abstract

Colorectal cancer (CRC) is currently the third most common malignancy world-wide, with an increasing mortality rate and treatment resistance. Due to the lack of effective biomarkers and therapeutic targets, the early diagnosis and treatment of colorectal cancer re-main suboptimal. Circular RNAs (circRNAs) are a novel class of non-coding RNAs with co-valent closed-loop structures that are well stabilized and conserved and are involved in multi-ple pathological conditions in humans. CircRNAs have been identified to be enriched and sta-ble in exosomes. In addition, there is growing proof that exosomal circRNAs that have been identified as oncogenes or tumor suppressors regulate CRC growth, migration, and sensitivity to radiotherapy and chemotherapy. Exosomal circRNAs represent promising candidates as di-agnostic biomarkers and anti-tumor targets. In this article, we explore recent studies on exo-somal circRNAs in CRC and describe their biological functions in colorectal cancer develop-ment, illustrating their potential as biomarkers and targeted therapeutic capabilities.

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外泌体 CircRNAs：结直肠癌的未来之星

结直肠癌（CRC）是目前全球第三大常见恶性肿瘤，死亡率和耐药性不断上升。由于缺乏有效的生物标志物和治疗靶点，结直肠癌的早期诊断和治疗仍不理想。环状 RNA（circRNA）是一类新型的非编码 RNA，具有共价闭环结构，具有良好的稳定性和保守性，参与人类多种病理状况。目前已发现外泌体中富含和存在 CircRNAs。此外，越来越多的证据表明，被鉴定为致癌基因或肿瘤抑制因子的外泌体 circRNA 可调控 CRC 的生长、迁移以及对放疗和化疗的敏感性。外泌体 circRNA 可作为双重诊断生物标志物和抗肿瘤靶点。在本文中，我们将探讨最近有关 CRC 外泌体 circRNAs 的研究，并描述它们在结直肠癌发展过程中的生物学功能，说明它们作为生物标志物和靶向治疗能力的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464