Lactylation: Linking the Warburg effect to DNA damage repair

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Analytical Chemistry Pub Date : 2024-08-06 DOI:10.1016/j.cmet.2024.06.015

引用次数: 0

Abstract

In this issue of Cell Metabolism, Li et al. report that the highly expressed aldehyde dehydrogenase 1 family member A3 interacts with pyruvate kinase M2 (PKM2) in glioblastoma cells. Consequently, PKM2 tetramerization and activation promote lactate production, leading to the lactylation and nuclear translocation of XRCC1 for DNA damage repair and therapeutic resistance.

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乳化作用：将沃伯格效应与 DNA 损伤修复联系起来

在本期《细胞新陈代谢》（Cell Metabolism）杂志上，Li等人报告说，在胶质母细胞瘤细胞中，高表达的醛脱氢酶1家族成员A3与丙酮酸激酶M2（PKM2）相互作用。因此，PKM2 的四聚体化和活化会促进乳酸的产生，从而导致 XRCC1 的乳化和核转运，以实现 DNA 损伤修复和抗药性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.