Lactylation: Linking the Warburg effect to DNA damage repair

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2024-08-06 DOI:10.1016/j.cmet.2024.06.015

引用次数: 0

Abstract

In this issue of Cell Metabolism, Li et al. report that the highly expressed aldehyde dehydrogenase 1 family member A3 interacts with pyruvate kinase M2 (PKM2) in glioblastoma cells. Consequently, PKM2 tetramerization and activation promote lactate production, leading to the lactylation and nuclear translocation of XRCC1 for DNA damage repair and therapeutic resistance.

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乳化作用：将沃伯格效应与 DNA 损伤修复联系起来

在本期《细胞新陈代谢》（Cell Metabolism）杂志上，Li等人报告说，在胶质母细胞瘤细胞中，高表达的醛脱氢酶1家族成员A3与丙酮酸激酶M2（PKM2）相互作用。因此，PKM2 的四聚体化和活化会促进乳酸的产生，从而导致 XRCC1 的乳化和核转运，以实现 DNA 损伤修复和抗药性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.