Metrnl: a promising biomarker and therapeutic target for cardiovascular and metabolic diseases.

IF 8.2 2区生物学 Q1 CELL BIOLOGY

Cell Communication and Signaling Pub Date : 2024-08-05 DOI:10.1186/s12964-024-01767-8

Wen-Sheng Dong, Can Hu, Min Hu, Yi-Peng Gao, Yu-Xin Hu, Kang Li, Yun-Jia Ye, Xin Zhang

引用次数: 0

Abstract

Modern human society is burdened with the pandemic of cardiovascular and metabolic diseases. Metrnl is a widely distributed secreted protein in the body, involved in regulating glucose and lipid metabolism and maintaining cardiovascular system homeostasis. In this review, we present the predictive and therapeutic roles of Metrnl in various cardiovascular and metabolic diseases, including atherosclerosis, ischemic heart disease, cardiac remodeling, heart failure, hypertension, chemotherapy-induced myocardial injury, diabetes mellitus, and obesity.

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Metrnl：心血管和新陈代谢疾病的有望生物标志物和治疗靶标。

现代人类社会普遍存在心血管疾病和代谢性疾病。Metrnl 是一种广泛分布于人体内的分泌蛋白，参与调节葡萄糖和脂质代谢，维持心血管系统的平衡。在这篇综述中，我们将介绍 Metrnl 在动脉粥样硬化、缺血性心脏病、心脏重塑、心力衰竭、高血压、化疗引起的心肌损伤、糖尿病和肥胖等各种心血管和代谢疾病中的预测和治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Communication and Signaling CELL BIOLOGY-

CiteScore

11.00

自引率

0.00%

发文量

180

期刊介绍： Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.