Experiences of early career researchers: Influences on the design and reporting of animal experiments, and the practical and emotional support needed to enhance best practice methods.

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-08-05 DOI:10.1177/00236772241242850
Heidi Morahan, Nicola Hancock, Lisa Bero, Kieron Rooney
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引用次数: 0

Abstract

While best practice methodology in animal research aims to address reproducibility and translational issues, awareness and implementation remains low. Preclinical systematic reviews have highlighted many flaws, including issues with internal validity and reporting. With early career researchers (ECRs) heavily involved in all aspects of animal experiments, it is crucial we understand what shapes their research practices. Semi-structured interviews were conducted with 13 ECRs, including research masters, PhD and postdoctoral academics. Data were collected and analysed concurrently using constant comparison techniques and an iterative approach. Findings revealed low-level awareness of best practice recommendations but a desire to engage in dedicated workshops on designing and reporting animal experiments. Current laboratory practices and previous literature were main influences on research practice, more than institutional training. An unexpected finding was the discovery of ethical and emotional dilemmas ECRs faced when working with animals. This highlights the need for a multifaceted approach to better support junior researchers, both emotionally and practically, to encourage responsible science.

早期职业研究人员的经验:对动物实验设计和报告的影响,以及加强最佳实践方法所需的实际和情感支持。
虽然动物研究的最佳实践方法旨在解决可重复性和转化问题,但人们的认识和实施程度仍然很低。临床前系统综述强调了许多缺陷,包括内部有效性和报告问题。早期职业研究人员(ECR)大量参与动物实验的各个方面,因此我们必须了解是什么影响了他们的研究实践。我们对 13 名 ECR(包括研究硕士、博士和博士后)进行了半结构式访谈。采用不断比较的技术和迭代的方法同时收集和分析数据。研究结果表明,他们对最佳实践建议的了解程度较低,但希望参加有关设计和报告动物实验的专门研讨会。当前的实验室实践和以前的文献是影响研究实践的主要因素,而不是机构培训。一个意想不到的发现是,ECR 在与动物共事时面临着伦理和情感困境。这突出表明,需要采取多方面的方法,从情感和实践两方面为初级研究人员提供更好的支持,以鼓励负责任的科学研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Laboratory Animals
Laboratory Animals 生物-动物学
CiteScore
4.90
自引率
8.30%
发文量
64
审稿时长
6-12 weeks
期刊介绍: The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.
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