Screening the quality of legal and illegal dietary supplements by LC-MS/MS.

IF 2.5 3区农林科学 Q2 CHEMISTRY, APPLIED

Food additives & contaminants. Part B, Surveillance Pub Date : 2024-08-06 DOI:10.1080/19393210.2024.2382221

Krzysztof Adam Stępień, Agnieszka Kalicka, Joanna Giebułtowicz

引用次数: 0

Abstract

Dietary supplements are widely consumed. However, the lack of mandatory testing results in limited data on their quality, particularly in Eastern Europe. In this study, 21 legally registered and 9 illegal supplements, seized from an underground facility by the Polish Police, were examined. Contaminants were screened by utilising high-performance liquid chromatography coupled with untargeted mass spectrometry. The analysis identified 32 contaminants in the 30 dietary supplements examined. Untargeted analysis revealed a concerning issue: the intentional adulteration of both legal and illegal supplements with pharmacologically active substances that are prohibited in this category of products. This study indicated that many dietary supplements are of low quality due to deliberate adulteration or inadequate manufacturing conditions. The presence of unregistered or unapproved substances in these supplements poses serious health risks. Strong legal regulations are essential to address this issue effectively.

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利用 LC-MS/MS 筛选合法和非法膳食补充剂的质量。

膳食补充剂被广泛食用。然而，由于缺乏强制性检测，有关其质量的数据十分有限，尤其是在东欧。在这项研究中，我们对波兰警方从地下设施中查获的 21 种合法注册营养补充剂和 9 种非法营养补充剂进行了检测。污染物的筛选采用了高效液相色谱法和非目标质谱法。分析确定了 30 种膳食补充剂中的 32 种污染物。非靶向分析揭示了一个令人担忧的问题：在合法和非法补充剂中故意掺入这类产品中禁止使用的药理活性物质。这项研究表明，由于故意掺假或生产条件不当，许多膳食补充剂质量低下。这些补充剂中含有未经注册或批准的物质，会对健康造成严重危害。要有效解决这一问题，必须制定强有力的法律法规。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food additives & contaminants. Part B, Surveillance 农林科学-毒理学

CiteScore

5.30

自引率

10.30%

发文量

审稿时长

2.7 months

期刊介绍： Food Additives & Contaminants: Part B publishes surveillance data indicating the presence and levels of occurrence of designated food additives, residues and contaminants in foods, food supplements and animal feed. Data using validated methods must meet stipulated quality standards to be acceptable and must be presented in a prescribed format for subsequent data-handling. Food Additives & Contaminants: Part B restricts its scope to include certain classes of food additives, residues and contaminants. This is based on a goal of covering those areas where there is a need to record surveillance data for the purposes of exposure and risk assessment. The scope is initially restricted to: Additives - food colours, artificial sweeteners, and preservatives; Residues – veterinary drug and pesticide residues; Contaminants – metals, mycotoxins, phycotoxins, plant toxins, nitrate/nitrite, PCDDs/PCFDs, PCBs, PAHs, acrylamide, 3-MPCD and contaminants derived from food packaging. Readership: The readership includes scientists involved in all aspects of food safety and quality and particularly those involved in monitoring human exposure to chemicals from the diet. Papers reporting surveillance data in areas other than the above should be submitted to Part A . The scope of Part B will be expanded from time-to-time to ensure inclusion of new areas of concern.