The Immunomodulatory Effects and Applications of Probiotic Lactiplantibacillus plantarum in Vaccine Development.

IF 4.4 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Probiotics and Antimicrobial Proteins Pub Date : 2024-12-01 Epub Date: 2024-08-05 DOI:10.1007/s12602-024-10338-9

Guiting He, Huanbing Long, Jiarong He, Cuiming Zhu

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Abstract

Lactiplantibacillus plantarum (previously known as Lactobacillus plantarum) is a lactic acid bacterium that exists in various niches. L. plantarum is a food-grade microorganism that is commonly considered a safe and beneficial microorganism. It is widely used in food fermentation, agricultural enhancement, and environmental protection. L. plantarum is also part of the normal flora that can regulate the intestinal microflora and promote intestinal health. Some strains of L. plantarum are powerful probiotics that induce and modulate the innate and adaptive immune responses. Due to its outstanding immunoregulatory capacities, an increasing number of studies have examined the use of probiotic L. plantarum strains as natural immune adjuvants or alternative live vaccine carriers. The present review summarizes the main immunomodulatory characteristics of L. plantarum and discusses the preliminary immunological effects of L. plantarum as a vaccine adjuvant and delivery carrier. Different methods for improving the immune capacities of recombinant vector vaccines are also discussed.

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植物乳杆菌的免疫调节作用及其在疫苗开发中的应用

植物乳杆菌（以前称作植物乳杆菌）是一种乳酸菌，存在于各种龛位中。植物乳杆菌是一种食品级微生物，通常被认为是一种安全有益的微生物。它被广泛用于食品发酵、农业增效和环境保护。植物乳杆菌也是正常菌群的一部分，可以调节肠道微生物菌群，促进肠道健康。植物乳杆菌的某些菌株是强大的益生菌，可诱导和调节先天性和适应性免疫反应。由于植物乳杆菌具有出色的免疫调节能力，越来越多的研究将植物乳杆菌益生菌株用作天然免疫佐剂或替代活疫苗载体。本综述总结了植物乳杆菌的主要免疫调节特性，并讨论了植物乳杆菌作为疫苗佐剂和输送载体的初步免疫学效果。此外还讨论了提高重组载体疫苗免疫能力的不同方法。

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来源期刊

Probiotics and Antimicrobial Proteins BIOTECHNOLOGY & APPLIED MICROBIOLOGYMICROB-MICROBIOLOGY

CiteScore

11.30

自引率

6.10%

发文量

140

期刊介绍： Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.