Circ_0006220 (circ-TADA2A) accelerates prostate cancer cell malignant behaviors through miR-520f-3p/CDCA7 axis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-28 DOI:10.14715/cmb/2024.70.7.12

Zijin Wan, Gang Liu

引用次数: 0

Abstract

Prostate cancer (PCa) belongs to a prevailing neoplasm globally. Circular RNAs (circRNAs) are critical regulators in various tumors, but the role of circRNAs in PCa is obscure. In this research, a circRNA derived from the TADA2A gene (hsa_circ_0006220) was high-expressed in PCa tissues along with cell lines. Elevated Circ-0006220 expression was also related to PCa poor prognosis. Besides, circ-0006220 accelerated PCa cells malignant behaviors in vitro; it also promoted PCa tumor growth together with metastasis in vivo. Moreover, circ-0006220 competed with the Cell Division Cycle Associated 7 (CDCA7) for binding to miR-520f-3p. Circ-0006220 sponged miR-520f-3p to regulate CDCA7 expression, thereby promoting PCa cell proliferation, migration, invasion, along with metastasis. All above data suggested that circ-0006220 may be a worthy target for PCa therapeutics.

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Circ_0006220（circ-TADA2A）通过 miR-520f-3p/CDCA7 轴加速前列腺癌细胞的恶性行为。

前列腺癌（PCa）是全球流行的肿瘤之一。环状 RNA（circRNA）是多种肿瘤的关键调控因子，但环状 RNA 在 PCa 中的作用尚不明确。在这项研究中，源自 TADA2A 基因的 circRNA（hsa_circ_0006220）在 PCa 组织和细胞系中高表达。Circ-0006220的高表达还与PCa的不良预后有关。此外，circ-0006220 在体外能加速 PCa 细胞的恶性行为，在体内也能促进 PCa 肿瘤的生长和转移。此外，circ-0006220还与细胞分裂周期相关7（CDCA7）竞争结合miR-520f-3p。circ-0006220通过调节miR-520f-3p来调控CDCA7的表达，从而促进PCa细胞的增殖、迁移、侵袭和转移。上述数据表明，circ-0006220可能是一个值得研究的治疗PCa的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.