The Association of Prothrombin Gene G20210A Mutation with Recurrent Venous Thromboembolism: Evidence from a Meta-Analysis.

IF 1.4 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Annals of vascular surgery Pub Date : 2024-08-07 DOI:10.1016/j.avsg.2024.06.044

Zaiqing Wang, Han Wu

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引用次数: 0

Abstract

Objectives: The prothrombin (PT) G20210A mutation is one of the most prevalent genetic variations associated with an increased susceptibility to the first episode of venous thromboembolism (VTE). However, it remains uncertain whether this inherited thrombophilic abnormality also poses a risk for recurrent VTE. This meta-analysis aimed to assess the relation of PT G20210A mutation to the risk of recurrent VTE.

Methods: PubMed and Scopus were systematically searched for pertinent prospective studies. Relative risks (RR) and 95% confidence intervals (CI) were used to test the association. Sixteen studies, with 16,174 participants, were included.

Results: Carriers of the G20210 A mutation were at increased risk of recurrent VTE (RR = 1.60, 95% CI = 1.20-2.14) compared to noncarriers; the increased risk was observed in heterozygotes (GA versus GG) (RR = 1.79, 95% CI = 1.24-2.57), but not in GA/AA mutation.

Conclusions: This association was found to be significant in the long term (≥5 years of follow-up), but not in the short term (<5 years of follow-up).

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凝血酶原基因 G20210A 突变与复发性静脉血栓栓塞症的关系：来自荟萃分析的证据。

目的：凝血酶原（PT）G20210A 突变是与静脉血栓栓塞症（VTE）首次发病易感性增加有关的最常见遗传变异之一。然而，这种遗传性血栓嗜性异常是否也会带来复发性 VTE 的风险，目前仍不确定。这项荟萃分析旨在评估 PT G20210A 突变与复发性 VTE 风险的关系：方法：系统检索了 PubMed 和 Scopus 上的相关前瞻性研究。采用相对风险（RR）和 95% 置信区间（CI）来检验两者之间的关系。共纳入16项研究，16174名参与者：与非携带者相比，G20210A 突变携带者发生复发性 VTE 的风险增加（RR=1.60，95%CI=1.20-2.14）；在杂合子（GA 与 GG）中观察到风险增加（RR=1.79，95%CI=1.24-2.57），但在 GA/AA 突变中未观察到风险增加：这种关联在长期（≥5 年的随访）中具有显著性，但在短期（≥5 年的随访）中不具有显著性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of vascular surgery 医学-外科

CiteScore

3.00

自引率

13.30%

发文量

603

审稿时长

50 days

期刊介绍： Annals of Vascular Surgery, published eight times a year, invites original manuscripts reporting clinical and experimental work in vascular surgery for peer review. Articles may be submitted for the following sections of the journal: Clinical Research (reports of clinical series, new drug or medical device trials) Basic Science Research (new investigations, experimental work) Case Reports (reports on a limited series of patients) General Reviews (scholarly review of the existing literature on a relevant topic) Developments in Endovascular and Endoscopic Surgery Selected Techniques (technical maneuvers) Historical Notes (interesting vignettes from the early days of vascular surgery) Editorials/Correspondence