An evaluation of a lateral flow rapid diagnostic test for Strongyloides stercoralis infection

IF 2.1 3区 医学 Q2 PARASITOLOGY
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Abstract

Strongyloides stercoralis in humans often presents as a chronic asymptomatic infection. Diagnosis can be challenging due to the limited sensitivity of faecal-based parasitological techniques. A prototype lateral flow rapid diagnostic test (RDT) for the detection of specific antibodies against Strongyloides stercoralis (SsRapid) was evaluated using 143 samples from the serum bank of the Swiss Tropical and Public Health Institute. Group 1 (n = 30) comprised serum samples from larvae-positive individuals; the RDT's diagnostic sensitivity was 97 % (29/30). Group II comprised serum samples from patients with other parasitic infections (n = 86) and Swiss blood donors (n = 27); the RDT's diagnostic specificity for this group was 90 % (102/113). The RDT showed good diagnostic performance and is a promising point-of-care test for detecting human Strongyloides stercoralis infection.

Abstract Image

盘尾丝虫感染侧流快速诊断检测的评估。
人体内的盘尾丝虫通常表现为慢性无症状感染。由于基于粪便的寄生虫学技术灵敏度有限,因此诊断具有挑战性。我们使用瑞士热带与公共卫生研究所血清库中的 143 份样本,对用于检测斯特龙线虫特异性抗体的侧流快速诊断测试(RDT)原型(SsRapid)进行了评估。第一组(30 人)为幼虫阳性者的血清样本;RDT 的诊断灵敏度为 97%(29/30)。第二组包括其他寄生虫感染患者(86 人)和瑞士献血者(27 人)的血清样本;该组的 RDT 诊断特异性为 90%(102/113)。RDT显示出良好的诊断性能,是一种很有前途的检测人类盘尾丝虫感染的床旁检测方法。
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来源期刊
Acta tropica
Acta tropica 医学-寄生虫学
CiteScore
5.40
自引率
11.10%
发文量
383
审稿时长
37 days
期刊介绍: Acta Tropica, is an international journal on infectious diseases that covers public health sciences and biomedical research with particular emphasis on topics relevant to human and animal health in the tropics and the subtropics.
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