Front Cover: Developing Low Molecular Weight PET and SPECT Imaging Agents (ChemMedChem 15/2024)

Abstract

The Front Cover shows the clinical demands that drive the development of novel imaging agents for positron emission tomography (PET) or single-photon emission computed tomography (SPECT). Multiple pathways lead from the initial concept to a practically useful compound. The process for the discovery and development of imaging agents follows a well-documented path; however, variations are possible and provide some flexibility depending on the resources and technologies available to the project team. According to the question asked, the properties of the imaging agents will vary, and the requirements for their development will differ. Understanding the target profile required to address the clinical questions, as well as the possible steps enabling the discovery, optimization, and validation of imaging agents is critical. Like when climbing a mountain, resource efficiency and speed should be optimized to guarantee the optimal development of novel imaging agent candidates. More details can be found in article 10.1002/cmdc.202400094 by Yves P. Auberson and co-workers.