The role of SIRT3 in homeostasis and cellular health

IF 4.2 3区医学 Q2 NEUROSCIENCES

Frontiers in Cellular Neuroscience Pub Date : 2024-08-02 DOI:10.3389/fncel.2024.1434459

Dennison Trinh, Lina Al Halabi, Harsimar Brar, Marie Kametani, Joanne E. Nash

引用次数: 0

Abstract

Mitochondria are responsible for maintaining cellular energy levels, and play a major role in regulating homeostasis, which ensures physiological function from the molecular to whole animal. Sirtuin 3 (SIRT3) is the major protein deacetylase of mitochondria. SIRT3 serves as a nutrient sensor; under conditions of mild metabolic stress, SIRT3 activity is increased. Within the mitochondria, SIRT3 regulates every complex of the electron transport chain, the tricarboxylic acid (TCA) and urea cycles, as well as the mitochondria membrane potential, and other free radical scavengers. This article reviews the role of SIRT3 in regulating homeostasis, and thus physiological function. We discuss the role of SIRT3 in regulating reactive oxygen species (ROS), ATP, immunological function and mitochondria dynamics.

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SIRT3 在平衡和细胞健康中的作用

线粒体负责维持细胞能量水平，并在调节体内平衡方面发挥重要作用，从而确保从分子到整个动物的生理功能。Sirtuin 3（SIRT3）是线粒体的主要蛋白质去乙酰化酶。SIRT3 是一种营养传感器；在轻微的代谢压力条件下，SIRT3 的活性会增加。在线粒体内，SIRT3 调节电子传递链、三羧酸（TCA）循环和尿素循环的每一个复合物，以及线粒体膜电位和其他自由基清除剂。本文回顾了 SIRT3 在调节体内平衡从而调节生理功能方面的作用。我们讨论了 SIRT3 在调节活性氧（ROS）、ATP、免疫功能和线粒体动力学方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cellular Neuroscience NEUROSCIENCES-

CiteScore

7.90

自引率

3.80%

发文量

627

审稿时长

6-12 weeks

期刊介绍： Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.