Long-term successfull management of recurrent episodes of nontuberculous mycobacterial infection in an apparently healthy Chinese woman

IF 4.6 2区医学 Q1 MICROBIOLOGY

Annals of Clinical Microbiology and Antimicrobials Pub Date : 2024-08-03 DOI:10.1186/s12941-024-00732-0

Angelo Roberto Raccagni, Giovanni Mori, Valeria Poletti de Chaurand, Raffaele Dell’Acqua, Daniela Maria Cirillo, Chiara Oltolini, Benedetta Mazzi, Francesco Scomazzoni, Antonella Castagna, Monica Guffanti

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引用次数: 0

Abstract

Disseminated non-tuberculous mycobacteria (dNTM) infections are mostly reported among individuals with an underlying congenital or acquired immunodeficiency or receiving immunosuppressive treatment, but are rarely documented in otherwise healthy subjects. We describe a case of recurrent disseminated mycobacterial infection in an apparently immunocompetent Chinese woman. Mycobacterium szulgai and Mycobacterium avium-complex were identified in distinct episodes. Long-term antimycobacterial therapy was administered given the occurrence of recurrent events when off-treatment. Successful management over more than 10 years and immunologic data are reported. This case-report highlights that dNTM should be suspected also among apparently immunocompetent hosts and that thorough assessment of underling immune-impairments is helpful to define patients’ management. Long-term antimycobacterial therapy and close monitoring is required to grant successful outcomes in case of recurrent dNTM infections.

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对一名表面健康的中国女性非结核分枝杆菌感染反复发作的长期成功治疗

播散性非结核分枝杆菌（dNTM）感染多见于患有先天性或获得性免疫缺陷或正在接受免疫抑制治疗的人群，但在其他健康人群中却鲜有报道。我们描述了一例表面上免疫功能正常的中国女性反复发生播散性分枝杆菌感染的病例。在不同的病例中发现了苏尔盖分枝杆菌和复合分枝杆菌。由于停药后会出现复发，因此进行了长期抗霉菌治疗。本病例报告了 10 多年来的成功治疗和免疫学数据。本病例报告强调，在免疫功能明显正常的宿主中也应怀疑 dNTM，对潜在的免疫缺陷进行全面评估有助于确定患者的治疗方案。需要进行长期的抗霉菌治疗和密切监测，以便在 dNTM 感染复发时取得成功。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical Microbiology and Antimicrobials MICROBIOLOGY-

CiteScore

8.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of Clinical Microbiology and Antimicrobials considers good quality, novel and international research of more than regional relevance. Research must include epidemiological and/or clinical information about isolates, and the journal covers the clinical microbiology of bacteria, viruses and fungi, as well as antimicrobial treatment of infectious diseases. Annals of Clinical Microbiology and Antimicrobials is an open access, peer-reviewed journal focusing on information concerning clinical microbiology, infectious diseases and antimicrobials. The management of infectious disease is dependent on correct diagnosis and appropriate antimicrobial treatment, and with this in mind, the journal aims to improve the communication between laboratory and clinical science in the field of clinical microbiology and antimicrobial treatment. Furthermore, the journal has no restrictions on space or access; this ensures that the journal can reach the widest possible audience.