Single and mixture exposure to atrazine and ciprofloxacin on Clarias gariepinus antioxidant defense status, hepatic condition and immune response

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-07-30 DOI:10.1016/j.etap.2024.104523

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引用次数: 0

Abstract

Atrazine (ATRA) and ciprofloxacin (CPRO) are widely detected, persistent and co-existing aquatic pollutants. This study investigated effects of 14-day single and joint ATRA and CPRO exposure on juvenile Clarias gariepinus. Standard bioassay methods were used to determine responses of oxidative stress, hepatic condition, and immunological biomarkers on days 7 and 14. Seven groups were used: Control, CPRO_EC, CPRO_Subl, ATRA_EC, ATRA_Subl, CPRO_EC+ATRA_EC, and CPRO_Subl+ATRA_Subl. The test substances caused decreased activity of superoxide dismutase, catalase, and glutathione peroxidase. Lipid peroxidation was elevated, especially in CPRO-ATRA mixtures. Serum aminotransferases (ALT, and AST), and alkaline phosphatase activity increased significantly. Total protein, albumin, total immunoglobulin, and respiratory burst decreased significantly. Therefore, single and joint exposure to CPRO and ATRA poses adverse consequences on aquatic life.

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阿特拉津和环丙沙星的单一和混合暴露对加里鱼抗氧化防御状态、肝脏状况和免疫反应的影响

阿特拉津（ATRA）和环丙沙星（CPRO）是广泛检测到的持久性共存水生污染物。本研究调查了单次和联合接触 ATRA 和 CPRO 14 天对幼鱼的影响。采用标准生物测定方法测定第 7 天和第 14 天的氧化应激反应、肝脏状况和免疫生物标志物。共使用了七个组：对照组、CPROEC组、CPROSubl组、ATRAEC组、ATRASubl组、CPROEC+ATRAEC组和CPROSubl+ATRASubl组。试验物质导致超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性降低。脂质过氧化反应升高，尤其是在 CPRO-ATRA 混合物中。血清转氨酶（ALT 和 AST）和碱性磷酸酶的活性显著增加。总蛋白、白蛋白、总免疫球蛋白和呼吸爆发明显下降。因此，单一或共同接触 CPRO 和 ATRA 会对水生生物造成不利影响。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.