Preventing radiation-induced dysphagia and trismus in head and neck cancer-A randomized controlled trial.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-08-01 DOI:10.1002/hed.27886

Kerstin Petersson, Caterina Finizia, Nina Pauli, Lisa Tuomi

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引用次数: 0

Abstract

Background: Radiation-induced dysphagia and restricted mouth opening are common problems among patients with head and neck cancer. The aim of the present randomized controlled trial was to determine if an exercise protocol could prevent swallowing and mouth opening impairment.

Methods: Eighty-nine participants were randomly assigned to either an active group performing preventive swallowing and mouth opening exercises (n = 45) or to a control group (n = 44). Outcome measures were collected at baseline before radiotherapy and approximately 1-month post-treatment. Primary endpoints were changes in swallowing function according to the Penetration Aspiration Scale and mouth opening ability measured in millimeters. Intention-to-treat analysis was used.

Results: Swallowing function and mouth opening deteriorated in both groups, with no statistically significant positive effect of the protocol detected at follow-up. Among patients who completed >75% of exercises, there was a trend toward better outcomes.

Conclusions: Preventive exercises did not improve short-term swallowing function and mouth opening after radiotherapy.

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预防头颈部癌症患者因辐射引起的吞咽困难和咀嚼障碍--随机对照试验。

背景：辐射引起的吞咽困难和张口受限是头颈部癌症患者的常见问题。本随机对照试验的目的是确定运动方案是否能预防吞咽和张口障碍：89 名参与者被随机分配到进行预防性吞咽和张口练习的积极组（n = 45）或对照组（n = 44）。结果测量在放疗前的基线和治疗后约 1 个月收集。主要终点是根据渗透吸入量表测量的吞咽功能变化和以毫米为单位测量的张口能力。采用意向治疗分析法：结果：两组患者的吞咽功能和张口能力都有所下降，但在随访中并未发现该方案在统计学上有显著的积极影响。结论：预防性锻炼并不能改善患者的短期吞咽功能：预防性锻炼并不能改善放疗后的短期吞咽功能和张口情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.