A rare case of acute cerebellitis due to enterovirus treated with therapeutic plasma exchange: Case report and review of the literature

IF 1.4 4区医学 Q4 HEMATOLOGY

Journal of Clinical Apheresis Pub Date : 2024-08-02 DOI:10.1002/jca.22142

Nihal Akçay, Neval Topal, Seda Yılmaz Semerci

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引用次数: 0

Abstract

Background

Acute cerebellitis is a rare complication of pediatric infections. There are many reports that viral infections lead to neurological manifestations, including acute cerebellitis.

Methods

A retrospective chart review was conducted for pediatric patients diagnosed with enterovirus cerebellitis between 2000 and 2024. The methods involved reviewing clinical and radiological records and assessing the treatment methods.

Results

Case Report

We present the case of a 4-year-old immunocompetent child who initially presented with acute encephalopathy followed by truncal ataxia, and eventually received a diagnosis of postinfectious cerebellitis. Enterovirus real-time polymerase chain reaction were positive in the nasopharyngeal swab. Therapeutic plasma exchange (TPE) was started due to neurological deterioration despite IVIG treatment. She improved significantly with TPE, and methylprednisolone treatment and was discharged in good health status. The patient is being followed up as neurologically normal.

Conclusion

Acute cerebellitis associated with enterovirus is a rare pediatric disorder. Early diagnosis and treatment with TPE in this severe case is thought to be preventive for the potentially fatal complications.

查看原文本刊更多论文

通过治疗性血浆置换治疗肠道病毒引起的急性小脑炎的罕见病例：病例报告和文献综述。

背景：急性小脑炎是一种罕见的小儿感染并发症。许多报道称病毒感染会导致神经系统表现，包括急性小脑炎：方法：对 2000 年至 2024 年期间诊断为肠道病毒小脑炎的儿科患者进行回顾性病历审查。方法：对 2000 年至 2024 年期间诊断为肠道病毒性小脑炎的儿童患者进行回顾性病历审查，包括审查临床和放射记录以及评估治疗方法：病例报告我们报告了一例 4 岁免疫功能正常儿童的病例，该患儿最初表现为急性脑病，随后出现躯干共济失调，最终被诊断为感染后小脑炎。鼻咽拭子中的肠道病毒实时聚合酶链反应呈阳性。由于尽管接受了 IVIG 治疗，但神经功能仍在恶化，因此开始进行治疗性血浆置换（TPE）。经过治疗性血浆置换和甲基强的松龙治疗后，她的病情明显好转，出院时健康状况良好。目前，该患者神经系统正常，正在接受随访：结论：与肠道病毒相关的急性小脑炎是一种罕见的儿科疾病。结论：与肠道病毒相关的急性小脑炎是一种罕见的儿科疾病，在这种严重的病例中，早期诊断和使用 TPE 治疗被认为可以预防潜在的致命并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Apheresis 医学-血液学

CiteScore

2.80

自引率

13.30%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Clinical Apheresis publishes articles dealing with all aspects of hemapheresis. Articles welcomed for review include those reporting basic research and clinical applications of therapeutic plasma exchange, therapeutic cytapheresis, therapeutic absorption, blood component collection and transfusion, donor recruitment and safety, administration of hemapheresis centers, and innovative applications of hemapheresis technology. Experimental studies, clinical trials, case reports, and concise reviews will be welcomed.