Fat-suppression T2 relaxation time and water fraction predict response to intravenous glucocorticoid therapy for thyroid-associated ophthalmopathy.

IF 4.7 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Radiology Pub Date : 2025-02-01 Epub Date: 2024-08-02 DOI:10.1007/s00330-024-10868-4

Linhan Zhai, Feng Li, Ban Luo, Qiuxia Wang, Hongyu Wu, Yali Zhao, Gang Yuan, Jing Zhang

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引用次数: 0

Abstract

Objective: To investigate the value of fat-suppression (FS) T2 relaxation time (T2RT) derived from FS T2 mapping and water fraction (WF) derived from T2 IDEAL to predict the treatment response to intravenous glucocorticoids (IVGC) in patients with thyroid-associated ophthalmopathy (TAO) based on texture analysis.

Materials and methods: In this study, 89 patients clinically diagnosed with active and moderate-to-severe TAO were enroled (responsive group, 48 patients; unresponsive group, 41 patients). The baseline clinical characteristics and texture features were compared between the two groups. Multivariate analysis was performed to identify the independent predictors of treatment response to IVGC. ROC analysis and the DeLong test were used to assess and compare the predictive performance of different models.

Results: The responsive group exhibited significantly shorter disease duration and higher 90th percentile of FS T2RT and kurtosis of WF in the extraocular muscle (EOM) and 95th percentile of WF in the orbital fat (OF) than the unresponsive group. Model 2 (disease duration + WF; AUC, 0.816) and model 3 (disease duration + FS T2RT + WF; AUC, 0.823) demonstrated superior predictive efficacy compared to model 1 (disease duration + FS T2RT; AUC, 0.756), while there was no significant difference between models 2 and 3.

Conclusions: The orbital tissues of responders exhibited more oedema and heterogeneity. Furthermore, OF is as valuable as EOM for assessing the therapeutic efficacy of IVGC. Finally, WF derived from T2 IDEAL processed by texture analysis can provide valuable information for predicting the treatment response to IVGC in patients with active and moderate-to-severe TAO.

Clinical relevance statement: The texture features of FS T2RT and WF are different between responders and non-responders, which can be the predictive tool for treatment response to IVGC.

Key points: Texture analysis can be used for predicting response to IVGC in TAO patients. TAO patients responsive to IVGC show more oedema and heterogeneity in the orbital tissues. WF from T2 IDEAL is a tool to predict the therapeutic response of TAO.

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脂肪抑制 T2 弛豫时间和水分数可预测甲状腺相关眼病患者对静脉注射糖皮质激素治疗的反应。

目的研究基于纹理分析的脂肪抑制（FS）T2弛豫时间（T2RT）和T2 IDEAL得出的水分数（WF）预测甲状腺相关性眼病（TAO）患者对静脉注射糖皮质激素（IVGC）治疗反应的价值：本研究共纳入89例临床诊断为活动性中重度TAO患者（有反应组48例，无反应组41例）。比较了两组患者的基线临床特征和纹理特征。为确定 IVGC 治疗反应的独立预测因素，进行了多变量分析。采用 ROC 分析和 DeLong 检验来评估和比较不同模型的预测性能：结果：与无反应组相比，有反应组的病程明显更短、眼外肌（EOM）FS T2RT第90百分位数和WF峰度更高、眼眶脂肪（OF）WF第95百分位数更高。与模型 1（病程 + FS T2RT；AUC，0.756）相比，模型 2（病程 + WF；AUC，0.816）和模型 3（病程 + FS T2RT + WF；AUC，0.823）显示出更优越的预测效果，而模型 2 和模型 3 之间没有显著差异：有反应者的眼眶组织表现出更多的水肿和异质性。此外，在评估 IVGC 的疗效方面，OF 与 EOM 具有同等价值。最后，通过纹理分析处理 T2 IDEAL 得出的 WF 可以为预测活动性中重度 TAO 患者对 IVGC 的治疗反应提供有价值的信息：FS T2RT和WF的纹理特征在有反应者和无反应者之间存在差异，可作为预测IVGC治疗反应的工具：纹理分析可用于预测TAO患者对IVGC的反应。要点：纹理分析可用于预测TAO患者对IVGC的反应，对IVGC有反应的TAO患者眼眶组织水肿和异质性更明显。T2 IDEAL的WF是预测TAO治疗反应的工具。

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来源期刊

European Radiology 医学-核医学

CiteScore

11.60

自引率

8.50%

发文量

874

审稿时长

2-4 weeks

期刊介绍： European Radiology (ER) continuously updates scientific knowledge in radiology by publication of strong original articles and state-of-the-art reviews written by leading radiologists. A well balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes ER an indispensable source for current information in this field. This is the Journal of the European Society of Radiology, and the official journal of a number of societies. From 2004-2008 supplements to European Radiology were published under its companion, European Radiology Supplements, ISSN 1613-3749.