The TOM complex from an evolutionary perspective and the functions of TOMM70.

IF 2.9 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Metin Özdemir, Sven Dennerlein
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引用次数: 0

Abstract

In humans, up to 1,500 mitochondrial precursor proteins are synthesized at cytosolic ribosomes and must be imported into the organelle. This is not only essential for mitochondrial but also for many cytosolic functions. The majority of mitochondrial precursor proteins are imported over the translocase of the outer membrane (TOM). In recent years, high-resolution structure analyses from different organisms shed light on the composition and arrangement of the TOM complex. Although significant similarities have been found, differences were also observed, which have been favored during evolution and could reflect the manifold functions of TOM with cellular signaling and its response to altered metabolic situations. A key component within these regulatory mechanisms is TOMM70, which is involved in protein import, forms contacts to the ER and the nucleus, but is also involved in cellular defense mechanisms during infections.

从进化角度看TOM复合体和TOMM70的功能。
在人类体内,多达 1,500 种线粒体前体蛋白是在细胞质核糖体上合成的,必须输入到细胞器中。这不仅是线粒体所必需的,也是许多细胞器功能所必需的。大多数线粒体前体蛋白都是通过外膜转运酶(TOM)导入的。近年来,来自不同生物体的高分辨率结构分析揭示了 TOM 复合物的组成和排列。虽然发现了许多相似之处,但也观察到了不同之处,这些不同之处在进化过程中得到了偏爱,并可能反映出 TOM 在细胞信号传递方面的多种功能及其对新陈代谢情况变化的反应。这些调控机制中的一个关键组成部分是 TOMM70,它参与蛋白质导入,与 ER 和细胞核形成接触,但也参与感染期间的细胞防御机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biological Chemistry
Biological Chemistry 生物-生化与分子生物学
CiteScore
7.20
自引率
0.00%
发文量
63
审稿时长
4-8 weeks
期刊介绍: Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences. Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published in a "Just Accepted" format within approx.72 hours of acceptance.
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