Immune checkpoints and pancreatic beta cell dysfunction in HIV.

IF 3.4 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2024-09-01 Epub Date: 2024-08-01 DOI:10.1097/QAD.0000000000003932

Luke A Pryke, Ziyue Liu, Alka K Khaitan, Emily K Sims, Samir K Gupta

引用次数: 0

Abstract

We explored the impact of immune dysregulation on pancreatic beta cell injury in HIV patients. Analyzing 105 participant samples, we observed lower IL-21 levels and elevated immune checkpoint levels (e.g. PD-1, CD27+, CD40+) in untreated HIV patients. Notably, soluble TIM-3 correlated positively with improved beta cell function and inversely with beta cell stress, suggesting its potential role in beta cell protection in untreated HIV.

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艾滋病毒的免疫检查点和胰腺β细胞功能障碍。

我们探讨了免疫失调对艾滋病患者胰腺β细胞损伤的影响。通过分析 105 例参与者样本，我们观察到未经治疗的 HIV 患者 IL-21 水平较低，免疫检查点水平（如 PD-1、CD27+、CD40+）升高。值得注意的是，可溶性 TIM-3 与β细胞功能的改善呈正相关，而与β细胞应激反应呈反相关，这表明它在未经治疗的 HIV 患者的β细胞保护中具有潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.