A Concise Review of the Synthesis and Applications of Acridine-1,8-dione Derivatives

Abstract

Over the past two decades, acridinediones have attracted considerable attention in organic and medicinal chemistry, drug discovery, and materials science. The present review covers recent literature on the synthesis of acridine-1,8-dione derivatives, including cyclocondensation and multicomponent reactions. These compounds exhibit significant biological activity and have found application in the production of antimicrobial, anticancer, and anti-inflammatory drugs. They are also used in materials science, acting as fluorescent probes. Recent advancements have been focused on developing more efficient synthetic approaches to acridine-1,8-diones and exploring novel applications. The versatility and wide range of functionalities make acridine-1,8-dione derivatives valuable in both pharmaceutical and industrial fields, highlighting their potential for future research and development.