Tirzepatide: A Double Agonist for Various People Living with Type 2 Diabetes.

IF 3.8 3区医学 Q2 Medicine

Diabetes Therapy Pub Date : 2024-09-01 Epub Date: 2024-07-31 DOI:10.1007/s13300-024-01624-4

Felice Strollo, Giuseppina Guarino, Ersilia Satta, Sandro Gentile

引用次数: 0

Abstract

Tirzepatide is the first ever once-weekly, injectable gastric inhibitory peptide/glucagon-like peptide 1 (GIP/GLP-1) dual agonist approved by the European Medicines Agency for type 2 diabetes. The efficacy and safety of tirzepatide have been evaluated in five global, randomized, double-blind or open-label, phase 3 studies which enrolled over 7000 people living with type 2 diabetes, across various stages of disease and with different characteristics at baseline. In this short commentary we report the salient data of the most recent trials on tirzepatide and GLP-1 receptor agonists from a clinical point of view, with the aim of highlighting similarities and mutual differences.

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替扎帕肽适用于各种 2 型糖尿病患者的双重激动剂。

替扎帕肽是欧洲药品管理局批准用于治疗 2 型糖尿病的首个每周注射一次的胃抑制肽/胰高血糖素样肽 1 (GIP/GLP-1) 双效激动剂。五项全球性、随机、双盲或开放标签的三期研究对替唑帕肽的疗效和安全性进行了评估，共有 7000 多名 2 型糖尿病患者参加了这些研究，他们的病情处于不同阶段，基线特征也各不相同。在这篇简短的评论中，我们从临床角度报告了有关替扎帕肽和 GLP-1 受体激动剂的最新试验的突出数据，旨在强调两者的相似之处和相互差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.90

自引率

7.90%

发文量

130

审稿时长

6 weeks

期刊介绍： Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.