Transcranial direct current stimulation improves tardive dyskinesia in long-term hospitalized patients with chronic schizophrenia

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-07-17 DOI:10.1016/j.clinph.2024.07.006

Xiaoli Lyu , Zhe Li , Siyu Chen , Shuguang Gu , Zhaoxin Zhou , Ruchang Yang , Ping Yang , Guangya Zhang , Chuanwei Li , Nian Yuan , Ming Yin , Wenyue Zhang , Xuexing Wei , Xiaoxia Huang , Xiangdong Du

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引用次数: 0

Abstract

Objective

This study aimed to evaluate the efficacy and safety of transcranial direct current stimulation (tDCS) in chronic schizophrenia patients with tardive dyskinesia (TD) who were long-term hospitalized.

Methods

Sixty-four inpatients who met the DSM-IV diagnostic criteria for schizophrenia and TD were randomly assigned to either the active (N=35) or sham (N=29) group. Treatment was given 15 times, with each session lasting for 30 min, and an intensity of 2 mA. The anode was placed on the left dorsolateral prefrontal cortex and the cathode on the right supraorbital region. Primary outcome was measured by the changes in Abnormal Involuntary Movements Scale (AIMS) score. Secondary outcomes were measured using the Positive and Negative Syndrome Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS). Adverse effects of tDCS were assessed with an experimenter-administered open-ended questionnaire throughout the experiment.

Results

Of the 64 patients, 52 (81.25%) completed the study. Compared to the sham group, patients in the active group exhibited a significant reduction in both the total AIMS score and the facial-oral subscore (P<0.05). An improvement of at least 30% in total AIMS scores was observed in the active group (14 patients, 50%) compared to the sham group (2 patients, 8.3%) after treatment (P<0.01). There were no between-group differences in the PANSS and SANS total scores. However, there was a significant difference between the two groups in the occurrence of the reported adverse effect of tingling sensation (P<0.05).

Conclusions

TDCS may be an effective and safe treatment for improving the facial-oral motor symptoms of TD in chronically hospitalized patients with schizophrenia.

Significance

This study provides a novel perspective for the clinical treatment of patients with TD.

查看原文本刊更多论文

经颅直流电刺激可改善长期住院的慢性精神分裂症患者的迟发性运动障碍。

研究目的本研究旨在评估经颅直流电刺激（tDCS）对长期住院的伴有迟发性运动障碍（TD）的慢性精神分裂症患者的疗效和安全性：64名符合DSM-IV精神分裂症和TD诊断标准的住院患者被随机分配到活性组（35人）或假性组（29人）。治疗共进行 15 次，每次持续 30 分钟，强度为 2 毫安。阳极置于左侧背外侧前额叶皮层，阴极置于右侧眶上区。主要结果通过异常不自主运动量表（AIMS）评分的变化来衡量。次要结果采用阳性和阴性综合征量表（PANSS）和阴性症状评估量表（SANS）进行测量。在整个实验过程中，使用实验者发放的开放式问卷对 tDCS 的不良反应进行评估：64名患者中，52人（81.25%）完成了研究。与假组相比较，活跃组患者的 AIMS 总分和面部-口腔子分数（PConclusions.TDCS）均有显著下降：TDCS可能是改善长期住院精神分裂症患者TD面口运动症状的一种有效而安全的治疗方法：本研究为TD患者的临床治疗提供了一个新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.