The mediating role of chronic low-grade inflammation participation in the relationship between obesity and type 2 diabetes: findings from the NHANES.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

BMC Endocrine Disorders Pub Date : 2024-07-31 DOI:10.1186/s12902-024-01671-9

Ping Li, Qincheng Qiao, Chenyu Nie, Xinghong Guo, Chuan Wang, Jinbo Liu, Kai Liang

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引用次数: 0

Abstract

Background: Chronic low-grade inflammation may mediate the relationship between obesity and diabetes, yet clinical research in this area remains scarce. Thus, this study aimed to explore the mediating role of chronic low-grade inflammation in this relationship using the National Health and Nutrition Examination Survey (NHANES).

Methods: This study involved 2,482 participants enrolled in the NHANES between 2005 and 2016. Based on the complex sampling survey weights of NHANES, logistic regression models were fitted, adjusting for various covariates to investigate the relationship between BMI, INFLA score, and diabetes. Moreover, weighted quantile sum (WQS) regression models were fitted to analyze the proportional contribution of individual components within the INFLA score. Finally, mediation analysis was conducted to quantitatively assess the magnitude of the mediating effect of the INFLA score on the relationship between BMI and diabetes.

Results: After adjusting for all potential confounding factors, a significant positive correlation was noted between INFLA score and diabetes [OR (95% CI), 1.038(1.003-1.075), p = 0.035]. Additionally, a significant positive correlation was observed between the high INFLA group and diabetes compared to the low INFLA group [OR (95% CI), 1.599(1.031-2.481), p = 0.037]. WQS regression models revealed that the proportional contributions of C-reactive protein, white blood cell count, platelet count, and neutrophil-to-lymphocyte ratio (NLR) were 55.5%, 34.8%, 8.46%, and 1.19%, respectively. Finally, the results of the mediation analysis indicated that the indirect effect of the INFLA score accounted for 10.20%.

Conclusions: Chronic low-grade inflammation was associated with diabetes and partially mediates the relationship between obesity and diabetes.

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慢性低度炎症参与在肥胖与 2 型糖尿病之间关系中的中介作用：NHANES 的研究结果。

背景：慢性低度炎症可能介导肥胖与糖尿病之间的关系，但这方面的临床研究仍然很少。因此，本研究旨在利用美国国家健康与营养调查（NHANES）来探讨慢性低度炎症在这一关系中的中介作用：本研究涉及 2005 年至 2016 年期间参加 NHANES 的 2482 名参与者。根据 NHANES 的复杂抽样调查权重，拟合了逻辑回归模型，并对各种协变量进行了调整，以研究 BMI、INFLA 评分和糖尿病之间的关系。此外，还拟合了加权量化和（WQS）回归模型，以分析 INFLA 分数中各个组成部分的贡献比例。最后，还进行了中介分析，以定量评估INFLA评分对体重指数与糖尿病之间关系的中介效应的大小：结果：在对所有潜在混杂因素进行调整后，INFLA 评分与糖尿病之间存在显著的正相关性[OR (95% CI)，1.038(1.003-1.075)，p = 0.035]。此外，与低 INFLA 组相比，高 INFLA 组与糖尿病之间存在明显的正相关性[OR（95% CI），1.599（1.031-2.481），p = 0.037]。WQS 回归模型显示，C 反应蛋白、白细胞计数、血小板计数和中性粒细胞与淋巴细胞比值（NLR）的贡献比例分别为 55.5%、34.8%、8.46% 和 1.19%。最后，中介分析结果表明，INFLA 评分的间接影响占 10.20%：慢性低度炎症与糖尿病有关，并部分介导了肥胖与糖尿病之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-

CiteScore

4.40

自引率

0.00%

发文量

280

审稿时长

>12 weeks

期刊介绍： BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.

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